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Combined Proteomic-...
Combined Proteomic-Molecular Epidemiology Approach to Identify Precision Targets in Brain Cancer
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- Mostovenko, Ekaterina (author)
- Virginia Commonwealth University
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- Liu, Yanhong (author)
- Baylor College of Medicine
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- Amirian, E. Susan (author)
- Baylor College of Medicine
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- Tsavachidis, Spiridon (author)
- Baylor College of Medicine
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- Armstrong, Georgina N. (author)
- Baylor College of Medicine
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- Bondy, Melissa L. (author)
- Baylor College of Medicine
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- Nilsson, Carol L. (author)
- Lund University,Lunds universitet,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2017-07-11
- 2018
- English 5 s.
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In: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 9:1, s. 80-84
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Abstract
Subject headings
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- Primary brain tumors are predominantly malignant gliomas. Grade IV astrocytomas (glioblastomas, GBM) are among the most deadly of all tumors; most patients will succumb to their disease within 2 years of diagnosis despite standard of care. The grim outlook for brain tumor patients indicates that novel precision therapeutic targets must be identified. Our hypothesis is that the cancer proteomes of glioma tumors may contain protein variants that are linked to the aggressive pathology of the disease. To this end, we devised a novel workflow that combined variant proteomics with molecular epidemiological mining of public cancer data sets to identify 10 previously unrecognized variants linked to the risk of death in low grade glioma or GBM. We hypothesize that a subset of the protein variants may be successfully developed in the future as novel targets for malignant gliomas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- drug target
- GBM
- Glioblastoma
- molecular epidemiology
- precision medicine
- proteomic
Publication and Content Type
- art (subject category)
- ref (subject category)
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