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  • Malik, Rainer (author)

Low-frequency and common genetic variation in ischemic stroke : The METASTROKE collaboration

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016
  • 10 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:95b30b07-4ef0-412b-a3b1-535d16124e54
  • https://lup.lub.lu.se/record/95b30b07-4ef0-412b-a3b1-535d16124e54URI
  • https://doi.org/10.1212/WNL.0000000000002528DOI
  • https://gup.ub.gu.se/publication/236994URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • OBJECTIVE: To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes.METHODS: We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p < 1E-5) in the discovery phase for replication in Caucasian (13,435 cases and 29,269 controls) and South Asian (2,385 cases and 5,193 controls) samples followed by a transethnic meta-analysis. We further investigated the p value distribution for different bins of allele frequencies for all IS and stroke subtypes.RESULTS: We showed genome-wide significance for 4 loci: ABO for all IS, HDAC9 for large vessel disease (LVD), and both PITX2 and ZFHX3 for cardioembolic stroke (CE). We further refined the association peaks for ABO and PITX2. Analyzing different allele frequency bins, we showed significant enrichment in low-frequency variants (allele frequency <5%) for both LVD and small vessel disease, and an enrichment of higher frequency variants (allele frequency 10% and 30%) for CE (all p < 1E-5).CONCLUSIONS: Our findings suggest that the missing heritability in IS subtypes can in part be attributed to low-frequency and rare variants. Larger sample sizes are needed to identify the variants associated with all IS and stroke subtypes.

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  • Traylor, Matthew (author)
  • Pulit, Sara L (author)
  • Bevan, Steve (author)
  • Hopewell, Jemma C (author)
  • Holliday, Elizabeth G (author)
  • Zhao, Wei (author)
  • Abrantes, Patricia (author)
  • Amouyel, Philippe (author)
  • Attia, John R (author)
  • Battey, Thomas W K (author)
  • Berger, Klaus (author)
  • Boncoraglio, Giorgio B (author)
  • Chauhan, Ganesh (author)
  • Cheng, Yu-Ching (author)
  • Chen, Wei-Min (author)
  • Clarke, Robert (author)
  • Cotlarciuc, Ioana (author)
  • Debette, Stephanie (author)
  • Falcone, Guido J (author)
  • Ferro, Jose M (author)
  • Gamble, Dale M (author)
  • Ilinca, AndreeaLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-ari (author)
  • Kittner, Steven J (author)
  • Kourkoulis, Christina E (author)
  • Lemmens, Robin (author)
  • Levi, Christopher R (author)
  • Lichtner, Peter (author)
  • Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups(Swepub:lu)neur-ali (author)
  • Liu, Jingmin (author)
  • Meschia, James F (author)
  • Mitchell, Braxton D (author)
  • Oliveira, Sofia A (author)
  • Pera, Joana (author)
  • Reiner, Alex P (author)
  • Rothwell, Peter M (author)
  • Sharma, Pankaj (author)
  • Slowik, Agnieszka (author)
  • Sudlow, Cathie L M (author)
  • Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xtatlt (author)
  • Thijs, Vincent (author)
  • Vicente, Astrid M (author)
  • Woo, Daniel (author)
  • Seshadri, Sudha (author)
  • Saleheen, Danish (author)
  • Rosand, Jonathan (author)
  • Markus, Hugh S (author)
  • Worrall, Bradford B (author)
  • Dichgans, Martin (author)
  • Neurologi, LundSektion IV (creator_code:org_t)
  • ISGC Analysis Group

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  • In:Neurology86:13, s. 26-12171526-632X

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