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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
- Mestdagh, P. (author)
-
- Fredlund, Erik (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
- Pattyn, F. (author)
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- Rihani, A. (author)
- Van Maerken, T. (author)
- Vermeulen, J. (author)
- Kumps, C. (author)
- Menten, B. (author)
- De Preter, K. (author)
- Schramm, A. (author)
- Schulte, J. (author)
- Noguera, R. (author)
- Schleiermacher, G. (author)
- Janoueix-Lerosey, I. (author)
- Laureys, G. (author)
- Powel, R. (author)
- Nittner, D. (author)
- Marine, J-C (author)
- Speleman, F. (author)
- Vandesompele, J. (author)
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- (creator_code:org_t)
- 2010-04-12
- 2010
- English.
- In: Oncogene. - : Springer Science and Business Media LLC. - 1476-5594 .- 0950-9232. ; 29:24, s. 3583-3592
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- non-coding RNA
- neuroblastoma
- T-UCR
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- art (subject category)
- ref (subject category)
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- Mestdagh, P.
- Fredlund, Erik
- Pattyn, F.
- Rihani, A.
- Van Maerken, T.
- Vermeulen, J.
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- Kumps, C.
- Menten, B.
- De Preter, K.
- Schramm, A.
- Schulte, J.
- Noguera, R.
- Schleiermacher, ...
- Janoueix-Lerosey ...
- Laureys, G.
- Powel, R.
- Nittner, D.
- Marine, J-C
- Ringnér, Markus
- Speleman, F.
- Vandesompele, J.
- show less...
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- Lund University
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