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An integrative geno...
An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-04-12
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Springer Science and Business Media LLC,2010
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:965ae2c6-2556-4dc2-86e7-f99a715ccb6f
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https://lup.lub.lu.se/record/1630286URI
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https://doi.org/10.1038/onc.2010.106DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010
Subject headings and genre
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Fredlund, ErikLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)molm-efr
(author)
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Pattyn, F.
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Rihani, A.
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Van Maerken, T.
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Vermeulen, J.
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Kumps, C.
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Menten, B.
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De Preter, K.
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Schramm, A.
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Schulte, J.
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Noguera, R.
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Schleiermacher, G.
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Janoueix-Lerosey, I.
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Laureys, G.
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Powel, R.
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Nittner, D.
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Marine, J-C
(author)
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Ringnér, MarkusLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thep-mri
(author)
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Speleman, F.
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Vandesompele, J.
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Bröstcancer-genetikSektion I
(creator_code:org_t)
Related titles
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In:Oncogene: Springer Science and Business Media LLC29:24, s. 3583-35921476-55940950-9232
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Oncogene
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Mestdagh, P.
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Fredlund, Erik
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Pattyn, F.
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Rihani, A.
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Van Maerken, T.
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Vermeulen, J.
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show more...
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Kumps, C.
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Menten, B.
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De Preter, K.
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Schramm, A.
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Schulte, J.
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Noguera, R.
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Schleiermacher, ...
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Janoueix-Lerosey ...
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Laureys, G.
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Powel, R.
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Nittner, D.
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Marine, J-C
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Ringnér, Markus
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Speleman, F.
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Vandesompele, J.
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- MEDICAL AND HEALTH SCIENCES
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Oncogene
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Lund University