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  • Mestdagh, P. (author)

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-04-12
  • Springer Science and Business Media LLC,2010

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:965ae2c6-2556-4dc2-86e7-f99a715ccb6f
  • https://lup.lub.lu.se/record/1630286URI
  • https://doi.org/10.1038/onc.2010.106DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fredlund, ErikLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)molm-efr (author)
  • Pattyn, F. (author)
  • Rihani, A. (author)
  • Van Maerken, T. (author)
  • Vermeulen, J. (author)
  • Kumps, C. (author)
  • Menten, B. (author)
  • De Preter, K. (author)
  • Schramm, A. (author)
  • Schulte, J. (author)
  • Noguera, R. (author)
  • Schleiermacher, G. (author)
  • Janoueix-Lerosey, I. (author)
  • Laureys, G. (author)
  • Powel, R. (author)
  • Nittner, D. (author)
  • Marine, J-C (author)
  • Ringnér, MarkusLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thep-mri (author)
  • Speleman, F. (author)
  • Vandesompele, J. (author)
  • Bröstcancer-genetikSektion I (creator_code:org_t)

Related titles

  • In:Oncogene: Springer Science and Business Media LLC29:24, s. 3583-35921476-55940950-9232

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