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Exposure-response r...
Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers
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- Welinder, Hans (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Jönsson, Bo A (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Nielsen, Jörn (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Ottosson, Helene (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Vidén, Cecilia (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 1994
- 1994
- Engelska.
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Ingår i: Scandinavian Journal of Work, Environment and Health. - 0355-3140. ; 20:6, s. 459-465
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- OBJECTIVES--Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. METHODS--The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 workers from two plants using epoxy resin with HHPA as a hardener; the mean time of exposure was 7 (range 0.1-25) years. RESULTS--The specific immunoglobin E and immunoglobin G was significantly increased in exposed workers when they were compared with unexposed workers or external referents. There was no significant difference in the number of RAST positives [N = 23 (24%)] between the groups of workers exposed to < 10 micrograms.m-3, 10--< 50 micrograms.m-3, or > or = 50 micrograms.m-3. No effects were found of atopy or smoking habits on the prevalence of RAST positives. Five out of seven workers positive for immunoglobulin E in the group with the lowest exposures reported frequent short-time (minutes per day) exposures exceeding 50 micrograms.m-3. A correlation was seen between specific immunoglobulin E and G antibodies (rs = 0.5). CONCLUSIONS--The results indicate that HHPA is a sensitizing compound even at low exposure levels and that short-time peak exposures may have an impact on immunoglobulin E sensitization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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