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Lymphomyeloid Contr...
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Böiers, CharlottaLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Utvecklingslymfopoes och leukemi,Forskargrupper vid Lunds universitet,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Developmental lymphopoiesis and leukemia,Lund University Research Groups
(author)
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.
- Article/chapterEnglish2013
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LIBRIS-ID:oai:lup.lub.lu.se:9737163f-4baf-4db0-9ed7-507f53fe30bf
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https://lup.lub.lu.se/record/4065547URI
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https://doi.org/10.1016/j.stem.2013.08.012DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128061315URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.
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Carrelha, Joana
(author)
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Lutteropp, Michael
(author)
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Luc, SidinhLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-sil
(author)
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Green, Joanna C A
(author)
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Azzoni, Emanuele
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Woll, Petter S
(author)
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Mead, Adam J
(author)
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Hultquist, AnneLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-ahu
(author)
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Swiers, Gemma
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Perdiguero, Elisa Gomez
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Macaulay, Iain C
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Melchiori, Luca
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Luis, Tiago C
(author)
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Kharazi, ShabnamLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-ksh
(author)
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Bouriez-Jones, Tiphaine
(author)
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Deng, QiaolinKarolinska Institutet
(author)
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Pontén, AnnicaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-anp
(author)
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Atkinson, Deborah
(author)
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Jensen, ChristinaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-cje
(author)
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Sitnicka Quinn, EwaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)molm-esi
(author)
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Geissmann, Frederic
(author)
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Godin, Isabelle
(author)
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Sandberg, RickardKarolinska Institutet
(author)
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de Bruijn, Marella F T R
(author)
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Jacobsen, Sten Eirik WKarolinska Institutet,Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-sja
(author)
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Avdelningen för molekylärmedicin och genterapiInstitutionen för laboratoriemedicin
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In:Cell Stem Cell: Elsevier BV13:5, s. 535-5481934-59091875-9777
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Böiers, Charlott ...
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Carrelha, Joana
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Lutteropp, Micha ...
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Luc, Sidinh
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Green, Joanna C ...
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Azzoni, Emanuele
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Woll, Petter S
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Mead, Adam J
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Hultquist, Anne
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Swiers, Gemma
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Perdiguero, Elis ...
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Macaulay, Iain C
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Melchiori, Luca
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Luis, Tiago C
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Kharazi, Shabnam
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Bouriez-Jones, T ...
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Deng, Qiaolin
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Pontén, Annica
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Atkinson, Debora ...
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Jensen, Christin ...
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Sitnicka Quinn, ...
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Geissmann, Frede ...
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Godin, Isabelle
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Sandberg, Rickar ...
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