SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:97446c64-d19f-43f8-813a-4ddd7dabbbbb"
 

Search: onr:"swepub:oai:lup.lub.lu.se:97446c64-d19f-43f8-813a-4ddd7dabbbbb" > Lymphoma risk in sy...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Bernatsky, Sasha (author)

Lymphoma risk in systemic lupus: effects of disease activity versus treatment

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2013-01-08
  • BMJ,2014

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:97446c64-d19f-43f8-813a-4ddd7dabbbbb
  • https://lup.lub.lu.se/record/4272240URI
  • https://doi.org/10.1136/annrheumdis-2012-202099DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). Methods We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated in regression models, for time-dependent exposures to immunomodulators (cyclophosphamide, azathioprine, methotrexate, mycophenolate, antimalarial drugs, glucocorticoids) demographics, calendar year, Sjogren's syndrome, SLE duration and disease activity. We used adjusted mean SLE Disease Activity Index scores (SLEDAI-2K) over time, and drugs were treated both categorically (ever/never) and as estimated cumulative doses. Results We studied 75 patients with lymphoma (72 non-Hodgkin, three Hodgkin) and 4961 cancer-free controls. Most lymphomas were of B-cell origin. As is seen in the general population, lymphoma risk in SLE was higher in male than female patients and increased with age. Lymphomas occurred a mean of 12.4years (median 10.9) after SLE diagnosis. Unadjusted and adjusted analyses failed to show a clear association of disease activity with lymphoma risk. There was a suggestion of greater exposure to cyclophosphamide and to higher cumulative steroids in lymphoma cases than the cancer-free controls. Conclusions In this large SLE sample, there was a suggestion of higher lymphoma risk with exposure to cyclophosphamide and high cumulative steroids. Disease activity itself was not clearly associated with lymphoma risk. Further work will focus on genetic profiles that might interact with medication exposure to influence lymphoma risk in SLE.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ramsey-Goldman, Rosalind (author)
  • Joseph, Lawrence (author)
  • Boivin, Jean-Francois (author)
  • Costenbader, Karen H. (author)
  • Urowitz, Murray B. (author)
  • Gladman, Dafna D. (author)
  • Fortin, Paul R. (author)
  • Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni (author)
  • Petri, Michelle A. (author)
  • Jacobsen, Soren (author)
  • Manzi, Susan (author)
  • Ginzler, Ellen M. (author)
  • Isenberg, David (author)
  • Rahman, Anisur (author)
  • Gordon, Caroline (author)
  • Ruiz-Irastorza, Guillermo (author)
  • Yelin, Edward (author)
  • Bae, Sang-Cheol (author)
  • Wallace, Daniel J. (author)
  • Peschken, Christine A. (author)
  • Dooley, Mary Anne (author)
  • Edworthy, Steven M. (author)
  • Aranow, Cynthia (author)
  • Kamen, Diane L. (author)
  • Romero-Diaz, Juanita (author)
  • Askanase, Anca (author)
  • Witte, Torsten (author)
  • Barr, Susan G. (author)
  • Criswell, Lindsey A. (author)
  • Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
  • Blanco, Irene (author)
  • Feldman, Candace H. (author)
  • Dreyer, Lene (author)
  • Patel, Neha M. (author)
  • St Pierre, Yvan (author)
  • Clarke, Ann E. (author)
  • Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

Related titles

  • In:Annals of the Rheumatic Diseases: BMJ73:1, s. 138-1421468-20600003-4967

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view