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Patient-reported ou...
Patient-reported outcomes in axial spondyloarthritis and psoriatic arthritis patients treated with secukinumab for 24 months in daily clinical practice
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- Christiansen, Sara Nysom (author)
- Copenhagen University Hospital
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- Horskjær Rasmussen, Simon (author)
- Copenhagen University Hospital
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- Pons, Marion (author)
- Copenhagen University Hospital
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- Michelsen, Brigitte (author)
- Diakonhjemmet Hospital,Copenhagen University Hospital
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- Glintborg, Bente (author)
- University of Copenhagen,Copenhagen University Hospital
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- Gudbjornsson, Bjorn (author)
- National University Hospital of Iceland
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- Grondal, Gerdur (author)
- National University Hospital of Iceland
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- Vencovsky, Jiri (author)
- Institute of Rheumatology, Prague,Charles University in Prague
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- Loft, Anne Gitte (author)
- Aarhus University Hospital,Aarhus University
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- Rotar, Ziga (author)
- University of Ljubljana,University Medical Centre Ljubljana
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- Pirkmajer, Katja Perdan (author)
- University of Ljubljana,University Medical Centre Ljubljana
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- Nissen, Michael J. (author)
- Geneva University Hospital
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Baranová, Jana (author)
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Macfarlane, Gary J. (author)
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Jones, Gareth T. (author)
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- Iannone, Florenzo (author)
- University of Bari Aldo Moro
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- Caporali, Roberto (author)
- University of Milan
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Laas, Karin (author)
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- Vorobjov, Sigrid (author)
- National Institute for Health Development, Estonia
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- Giuseppe, Daniela Di (author)
- Karolinska Institutet,Karolinska Institute
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- Olofsson, Tor (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Provan, Sella Aarrestad (author)
- Inland Norway University of Applied Sciences,Diakonhjemmet Hospital
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- Fagerli, Karen Minde (author)
- Diakonhjemmet Hospital
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- Castrejon, Isabel (author)
- Hospital Gregorio Maranon,Complutense University of Madrid
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Otero-Varela, Lucia (author)
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- van de Sande, Marleen (author)
- University of Amsterdam
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- van der Horst-Bruinsma, Irene (author)
- Radboud University Medical Center
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- Nordström, Dan (author)
- Helsinki University Central Hospital
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- Kuusalo, Laura (author)
- University of Turku
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- Bernardes, Miguel (author)
- University of Porto
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- Hetland, Merete Lund (author)
- Copenhagen University Hospital,University of Copenhagen
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- Østergaard, Mikkel (author)
- University of Copenhagen,Copenhagen University Hospital
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- Midtbøll Ørnbjerg, Lykke (author)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Seminars in Arthritis and Rheumatism. - 0049-0172 .- 1532-866X. ; 65
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates. Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care were included. PRO remission rates were defined as pain, fatigue, Patient Global Assessment (PGA) ≤2 (Numeric Rating Scale (NRS) 0–10) and Health Assessment Questionnaire (HAQ) ≤0.5, for both axSpA and PsA, and were calculated as crude values and adjusted for drug adherence (LUNDEX). Comparisons of axSpA and PsA remission rates were performed using logistic regression analyses (unadjusted and adjusted for multiple confounders). Kaplan-Meier plots with log-rank test and Cox regression analyses were conducted to assess and compare secukinumab retention rates. Results: We included 3087 axSpA and 3246 PsA patients initiating secukinumab. Crude pain, fatigue, PGA and HAQ remission rates were higher in axSpA than in PsA patients, whereas LUNDEX-adjusted remission rates were similar. No differences were found between the patient groups after adjustment for confounders. The 24-month retention rates were similar in axSpA vs. PsA in fully adjusted analyses (HR [95 %CI] = 0.92 [0.84–1.02]). Conclusion: In this large European real-world study of axSpA and PsA patients treated with secukinumab, we demonstrate for the first time a comparable effectiveness in PRO remission and treatment retention rates between these two conditions when adjusted for confounders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Biologic therapy
- Clinical study in epidemiology
- Cohort study
- Rheumatic diseases
- Spondyloarthritis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Christiansen, Sa ...
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Horskjær Rasmuss ...
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Pons, Marion
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Michelsen, Brigi ...
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Glintborg, Bente
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Gudbjornsson, Bj ...
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Grondal, Gerdur
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Vencovsky, Jiri
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Loft, Anne Gitte
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Rotar, Ziga
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Pirkmajer, Katja ...
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Nissen, Michael ...
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Baranová, Jana
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Macfarlane, Gary ...
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Jones, Gareth T.
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Iannone, Florenz ...
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Caporali, Robert ...
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Laas, Karin
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Vorobjov, Sigrid
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Giuseppe, Daniel ...
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Olofsson, Tor
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Provan, Sella Aa ...
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Fagerli, Karen M ...
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Castrejon, Isabe ...
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Otero-Varela, Lu ...
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van de Sande, Ma ...
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van der Horst-Br ...
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Nordström, Dan
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Kuusalo, Laura
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Bernardes, Migue ...
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Hetland, Merete ...
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Østergaard, Mikk ...
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Midtbøll Ørnbjer ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Seminars in Arth ...
- By the university
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Lund University
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Karolinska Institutet