Search: onr:"swepub:oai:lup.lub.lu.se:9827d555-9fe0-4af3-aba4-f0b42718d772" >
Immunoglobulin D en...
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils
-
Chen, Kang (author)
-
Xu, Weifeng (author)
-
Wilson, Melanie (author)
-
show more...
-
He, Bing (author)
-
Miller, Norman W. (author)
-
Bengten, Eva (author)
-
Edholm, Eva-Stina (author)
-
Santini, Paul A. (author)
-
Rath, Poonam (author)
-
Chiu, April (author)
-
Cattalini, Marco (author)
-
Litzman, Jiri (author)
-
Bussel, James B. (author)
-
Huang, Bihui (author)
-
Meini, Antonella (author)
-
- Riesbeck, Kristian (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
-
Cunningham-Rundles, Charlotte (author)
-
Plebani, Alessandro (author)
-
Cerutti, Andrea (author)
-
show less...
-
(creator_code:org_t)
- 2009-06-28
- 2009
- English.
-
In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 10:8, s. 121-889
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Chen, Kang
-
Xu, Weifeng
-
Wilson, Melanie
-
He, Bing
-
Miller, Norman W ...
-
Bengten, Eva
-
show more...
-
Edholm, Eva-Stin ...
-
Santini, Paul A.
-
Rath, Poonam
-
Chiu, April
-
Cattalini, Marco
-
Litzman, Jiri
-
Bussel, James B.
-
Huang, Bihui
-
Meini, Antonella
-
Riesbeck, Kristi ...
-
Cunningham-Rundl ...
-
Plebani, Alessan ...
-
Cerutti, Andrea
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
- Articles in the publication
-
Nature Immunolog ...
- By the university
-
Lund University