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Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils
- Chen, Kang (author)
- Xu, Weifeng (author)
- Wilson, Melanie (author)
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- He, Bing (author)
- Miller, Norman W. (author)
- Bengten, Eva (author)
- Edholm, Eva-Stina (author)
- Santini, Paul A. (author)
- Rath, Poonam (author)
- Chiu, April (author)
- Cattalini, Marco (author)
- Litzman, Jiri (author)
- Bussel, James B. (author)
- Huang, Bihui (author)
- Meini, Antonella (author)
- Cunningham-Rundles, Charlotte (author)
- Plebani, Alessandro (author)
- Cerutti, Andrea (author)
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- (creator_code:org_t)
- 2009-06-28
- 2009
- English.
- In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 10:8, s. 121-889
- Journal article (peer-reviewed)
Abstract
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- Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- Xu, Weifeng
- Wilson, Melanie
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- Santini, Paul A.
- Rath, Poonam
- Chiu, April
- Cattalini, Marco
- Litzman, Jiri
- Bussel, James B.
- Huang, Bihui
- Meini, Antonella
- Riesbeck, Kristi ...
- Cunningham-Rundl ...
- Plebani, Alessan ...
- Cerutti, Andrea
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