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Immunoglobulin D en...
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-06-28
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Springer Science and Business Media LLC,2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:9827d555-9fe0-4af3-aba4-f0b42718d772
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https://lup.lub.lu.se/record/1461428URI
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https://doi.org/10.1038/ni.1748DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.
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Xu, Weifeng
(author)
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Wilson, Melanie
(author)
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He, Bing
(author)
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Miller, Norman W.
(author)
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Bengten, Eva
(author)
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Edholm, Eva-Stina
(author)
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Santini, Paul A.
(author)
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Rath, Poonam
(author)
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Chiu, April
(author)
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Cattalini, Marco
(author)
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Litzman, Jiri
(author)
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Bussel, James B.
(author)
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Huang, Bihui
(author)
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Meini, Antonella
(author)
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Riesbeck, KristianLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-kri
(author)
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Cunningham-Rundles, Charlotte
(author)
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Plebani, Alessandro
(author)
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Cerutti, Andrea
(author)
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Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Nature Immunology: Springer Science and Business Media LLC10:8, s. 121-8891529-29081529-2916
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Chen, Kang
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Xu, Weifeng
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Wilson, Melanie
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He, Bing
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Miller, Norman W ...
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Bengten, Eva
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Edholm, Eva-Stin ...
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Santini, Paul A.
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Rath, Poonam
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Chiu, April
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Cattalini, Marco
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Litzman, Jiri
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Bussel, James B.
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Huang, Bihui
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Meini, Antonella
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Riesbeck, Kristi ...
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Cunningham-Rundl ...
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Plebani, Alessan ...
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Cerutti, Andrea
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- MEDICAL AND HEALTH SCIENCES
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Nature Immunolog ...
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Lund University