Omega-3 fatty acids for inflamed depression - A match/mismatch study

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Omega-3 fatty acids for inflamed depression - A match/mismatch study

Suneson, Klara (author): Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups

Söderberg Veibäck, Gustav (author): Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups,Skåne University Hospital

Lindahl, Jesper (author): Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups

Tjernberg, Johanna (author): Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups

Ståhl, Darya (author): Lund University,Lunds universitet,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Unit for Biological and Precision Psychiatry,Lund University Research Groups

Ventorp, Simon (author): Lund University

Ängeby, Filip (author): Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups

Lundblad, Karl (author): Stockholm Regional Council

Wolkowitz, Owen M (author): University of California System

Lindqvist, Daniel (author): Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas

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2024
2024
English.
In: Brain, Behavior, and Immunity. - 1090-2139. ; 118, s. 192-201

Related links:: http://dx.doi.org/10... (free); show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Despite decades of research on the pathophysiology of depression, the development of new therapeutic interventions has been slow, and no biomarkers of treatment response have been clinically implemented. Several lines of evidence suggest that the clinical and biological heterogeneity among patients with major depressive disorder (MDD) has hampered progress in this field. MDD with low-grade inflammation - "inflamed depression" - is a subtype of depression that may be associated with a superior antidepressant treatment response to anti-inflammatory compounds. Omega-3 fatty acid eicosapentaenoic acid (EPA) has anti-inflammatory properties, and preliminary data suggest that it may be particularly efficacious in inflamed depression. In this study we tested the hypothesis that add-on EPA has greater antidepressant efficacy in MDD patients with high baseline high-sensitivity C-reactive protein (hs-CRP) compared to MDD patients with low hs-CRP. All subjects received 2.2 g EPA, 400 mg docosahexaenoic acid and 800 mg of other fatty acids daily for 8 weeks, added to stable ongoing antidepressant treatment. The primary outcome was change in the 17-item Hamilton Depression Rating Scale (HAMD-17). Patients and raters were blind to baseline hs-CRP status. In an intention-to-treat analysis including all subjects with at least one post baseline visit (n = 101), ahs-CRPcut-off of ≥1 mg/L, but not ≥3 mg/L, was associated with a greater improvement in HAMD-17 total score. In addition to a general antidepressant effect among patients with hs-CRP ≥ 1 mg/L, adjuvant EPA treatment improved symptoms putatively related to inflamed depression such as fatigue and sleep difficulties. This adds to the mounting evidence that delineation of MDD subgroups based on inflammation may be clinically relevant to predict treatment response to anti-inflammatory interventions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)

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By the author/editor: Suneson, Klara; Söderberg Veibäc ...; Lindahl, Jesper; Tjernberg, Johan ...; Ståhl, Darya; Ventorp, Simon; show more...; Ängeby, Filip; Lundblad, Karl; Wolkowitz, Owen ...; Lindqvist, Danie ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Brain, Behavior, ...

By the university: Lund University

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