Search: onr:"swepub:oai:lup.lub.lu.se:991a59ec-531d-46dd-80c5-01e928e403eb" >
Human iPS cell-deri...
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model
-
- Kikuchi, Tetsuhiro (author)
- Kyoto University
-
- Morizane, Asuka (author)
- Kyoto University
-
- Doi, Daisuke (author)
- Kyoto University
-
show more...
-
- Magotani, Hiroaki (author)
- Kyoto University
-
- Onoe, Hirotaka (author)
- RIKEN Nishina Center for Accelerator-Based Science
-
- Hayashi, Takuya (author)
- RIKEN Nishina Center for Accelerator-Based Science
-
- Mizuma, Hiroshi (author)
- RIKEN Nishina Center for Accelerator-Based Science
-
- Takara, Sayuki (author)
- RIKEN Nishina Center for Accelerator-Based Science
-
- Takahashi, Ryosuke (author)
- Kyoto University
-
- Inoue, Haruhisa (author)
- Kyoto University
-
- Morita, Satoshi (author)
- Kyoto University
-
- Yamamoto, Michio (author)
- Kyoto University
-
- Okita, Keisuke (author)
- Kyoto University
-
- Nakagawa, Masato (author)
- Kyoto University
-
- Parmar, Malin (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
-
- Takahashi, Jun (author)
- Kyoto University
-
show less...
-
(creator_code:org_t)
- 2017-08-31
- 2017
- English 5 s.
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 548:7669, s. 592-596
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate. However, long-term analysis of human iPS cell-derived dopaminergic neurons in primate PD models has never been performed to our knowledge. Here we show that human iPS cell-derived dopaminergic progenitor cells survived and functioned as midbrain dopaminergic neurons in a primate model of PD (Macaca fascicularis) treated with the neurotoxin MPTP. Score-based and video-recording analyses revealed an increase in spontaneous movement of the monkeys after transplantation. Histological studies showed that the mature dopaminergic neurons extended dense neurites into the host striatum; this effect was consistent regardless of whether the cells were derived from patients with PD or from healthy individuals. Cells sorted by the floor plate marker CORIN did not form any tumours in the brains for at least two years. Finally, magnetic resonance imaging and positron emission tomography were used to monitor the survival, expansion and function of the grafted cells as well as the immune response in the host brain. Thus, this preclinical study using a primate model indicates that human iPS cell-derived dopaminergic progenitors are clinically applicable for the treatment of patients with PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Nature
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Kikuchi, Tetsuhi ...
-
Morizane, Asuka
-
Doi, Daisuke
-
Magotani, Hiroak ...
-
Onoe, Hirotaka
-
Hayashi, Takuya
-
show more...
-
Mizuma, Hiroshi
-
Takara, Sayuki
-
Takahashi, Ryosu ...
-
Inoue, Haruhisa
-
Morita, Satoshi
-
Yamamoto, Michio
-
Okita, Keisuke
-
Nakagawa, Masato
-
Parmar, Malin
-
Takahashi, Jun
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Nature
- By the university
-
Lund University