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Dendritic cell vacc...
Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia
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- Anguille, Sébastien (author)
- University of Antwerp,Antwerp University Hospital
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- Van De Velde, Ann L. (author)
- University of Antwerp,Antwerp University Hospital
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- Smits, Evelien L. (author)
- University of Antwerp
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- Van Tendeloo, Viggo F. (author)
- University of Antwerp
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Skåne University Hospital
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- Cools, Nathalie (author)
- University of Antwerp
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- Nijs, Griet (author)
- University of Antwerp,Antwerp University Hospital
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- Stein, Barbara (author)
- Antwerp University Hospital,University of Antwerp
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- Lion, Eva (author)
- University of Antwerp
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- Driessche, Ann Van (author)
- University of Antwerp,Antwerp University Hospital
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- Vandenbosch, Irma (author)
- Antwerp University Hospital
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- Verlinden, Anke (author)
- Antwerp University Hospital,University of Antwerp
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- Gadisseur, Alain P. (author)
- Antwerp University Hospital,University of Antwerp
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- Schroyens, Wilfried A. (author)
- Antwerp University Hospital,University of Antwerp
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- Muylle, Ludo (author)
- University of Antwerp,Antwerp University Hospital
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- Vermeulen, Katrien (author)
- Antwerp University Hospital
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- Maes, Marie Berthe (author)
- Antwerp University Hospital
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- Deiteren, Kathleen (author)
- Antwerp University Hospital
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- Malfait, Ronald (author)
- Antwerp University Hospital
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- Gostick, Emma (author)
- Cardiff University
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- Lammens, Martin (author)
- Antwerp University Hospital
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- Couttenye, Marie M. (author)
- Antwerp University Hospital
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- Jorens, Philippe (author)
- Antwerp University Hospital
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- Goossens, Herman (author)
- University of Antwerp,Antwerp University Hospital
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- Price, David A. (author)
- Cardiff University
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- Ladell, Kristin (author)
- Cardiff University
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- Oka, Yoshihiro (author)
- Osaka University
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- Fujiki, Fumihiro (author)
- Osaka University
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- Oji, Yusuke (author)
- Osaka University
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- Sugiyama, Haruo (author)
- Osaka University
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- Berneman, Zwi N. (author)
- University of Antwerp,Antwerp University Hospital
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(creator_code:org_t)
- American Society of Hematology, 2017
- 2017
- English 9 s.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 130:15, s. 1713-1721
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
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- Relapse is a major problem in acute myeloid leukemia (AML) and adversely affects survival. In this phase 2 study, we investigated the effect of vaccination with dendritic cells (DCs) electroporated with Wilms’ tumor 1 (WT1) messenger RNA (mRNA) as postremission treatment in 30 patients with AML at very high risk of relapse. There was a demonstrable antileukemic response in 13 patients. Nine patients achieved molecular remission as demonstrated by normalization of WT1 transcript levels, 5 of which were sustained after a median follow-up of 109.4 months. Disease stabilization was achieved in 4 other patients. Five-year overall survival (OS) was higher in responders than in nonresponders (53.8% vs 25.0%; P 5 .01). In patients receiving DCs in first complete remission (CR1), there was a vaccine-induced relapse reduction rate of 25%, and 5-year relapse-free survival was higher in responders than in nonresponders (50% vs 7.7%; P < .0001). In patients age £65 and >65 years who received DCs in CR1, 5-year OS was 69.2% and 30.8% respectively, as compared with 51.7% and 18% in the Swedish Acute Leukemia Registry. Long-term clinical response was correlated with increased circulating frequencies of polyepitope WT1-specific CD81 T cells. Long-term OS was correlated with interferon-g1 and tumor necrosis factor-a1 WT1-specific responses in delayed-type hypersensitivity-infiltrating CD81 T lymphocytes. In conclusion, vaccination of patients with AML with WT1 mRNA-electroporated DCs can be an effective strategy to prevent or delay relapse after standard chemotherapy, translating into improved OS rates, which are correlated with the induction of WT1-specific CD81 T-cell response. This trial was registered at www.clinicaltrials.gov as #NCT00965224.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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- By the author/editor
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Anguille, Sébast ...
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Van De Velde, An ...
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Smits, Evelien L ...
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Van Tendeloo, Vi ...
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Juliusson, Gunna ...
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Cools, Nathalie
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show more...
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Nijs, Griet
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Stein, Barbara
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Lion, Eva
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Driessche, Ann V ...
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Vandenbosch, Irm ...
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Verlinden, Anke
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Gadisseur, Alain ...
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Schroyens, Wilfr ...
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Muylle, Ludo
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Vermeulen, Katri ...
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Maes, Marie Bert ...
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Deiteren, Kathle ...
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Malfait, Ronald
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Gostick, Emma
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Lammens, Martin
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Couttenye, Marie ...
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Jorens, Philippe
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Goossens, Herman
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Price, David A.
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Ladell, Kristin
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Oka, Yoshihiro
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Fujiki, Fumihiro
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Oji, Yusuke
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Sugiyama, Haruo
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Berneman, Zwi N.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Blood
- By the university
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Lund University