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Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis
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- Holm, L (author)
- Umeå universitet,Kemiska institutionen
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- Kjellen, P (author)
- Section of Medical Inflammation Research, Lund University, Lund, Sweden
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- Holmdahl, Rikard (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Section of Medical Inflammation Research, Lund University, Lund, Sweden
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- (creator_code:org_t)
- Oxford : Elsevier BV, 2005
- 2005
- English.
- In: Bioorganic & Medicinal Chemistry. - Oxford : Elsevier BV. - 0968-0896 .- 1464-3391. ; 13:2, s. 473-482
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Collagen induced arthritis (CIA) is a common mouse model for rheumatoid arthritis. Two sets of truncated peptides derived from type II collagen have been prepared and tested for binding to A(q), a MHC-II molecule associated with development of CIA. Binding to A(q) correlated well with predictions from a computer-based model. T-cell hybridomas, obtained in CIA, were also used to study the ability of A(q) bound peptides to trigger a T-cell response. The minimal peptide epitope required for binding, as well as for giving a T-cell response, was determined to be CII260-267. In collagen this epitope is often glycosylated at hydroxylysine 264 and glycosylation has been shown to be an immunodominant feature in CIA. Synthesis and evaluation of CII260-267 carrying a beta-D-galactosyl moiety at position 264 revealed that this glycopeptide stimulated representative members from a panel of carbohydrate-specific T-cell hybridomas obtained in CIA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- T cell
- glycopeptide
- collagen
- rheumatoid arthritis
- Glycopeptide
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Holm, L
- Kjellen, P
- Holmdahl, Rikard
- Kihlberg, J
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