Search: onr:"swepub:oai:lup.lub.lu.se:99652da4-3dd8-4107-adfe-b3a1f6f5d607" >
Variants in MTNR1B ...
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Prokopenko, Inga
(author)
Variants in MTNR1B influence fasting glucose levels
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2008-12-07
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Springer Science and Business Media LLC,2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:99652da4-3dd8-4107-adfe-b3a1f6f5d607
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https://lup.lub.lu.se/record/1313201URI
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https://doi.org/10.1038/ng.290DOI
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https://gup.ub.gu.se/publication/184433URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.
Subject headings and genre
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Langenberg, Claudia
(author)
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Florez, Jose C.
(author)
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Saxena, Richa
(author)
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Soranzo, Nicole
(author)
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Thorleifsson, Gudmar
(author)
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Loos, Ruth J. F.
(author)
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Manning, Alisa K.
(author)
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Jackson, Anne U.
(author)
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Aulchenko, Yurii
(author)
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Potter, Simon C.
(author)
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Erdos, Michael R.
(author)
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Sanna, Serena
(author)
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Hottenga, Jouke-Jan
(author)
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Wheeler, Eleanor
(author)
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Kaakinen, Marika
(author)
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
(author)
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Chen, Wei-Min
(author)
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Ahmadi, Kourosh
(author)
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Beckmann, Jacques S.
(author)
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Bergman, Richard N.
(author)
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Bochud, Murielle
(author)
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Bonnycastle, Lori L.
(author)
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Buchanan, Thomas A.
(author)
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Cao, Antonio
(author)
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Cervino, Alessandra
(author)
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Coin, Lachlan
(author)
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Collins, Francis S.
(author)
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Crisponi, Laura
(author)
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De Geus, Eco J. C.
(author)
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Dehghan, Abbas
(author)
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Deloukas, Panos
(author)
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Doney, Alex S. F.
(author)
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Elliott, Paul
(author)
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Freimer, Nelson
(author)
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Gateva, Vesela
(author)
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Herder, Christian
(author)
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Hofman, Albert
(author)
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Hughes, Thomas E.
(author)
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Hunt, Sarah
(author)
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Illig, Thomas
(author)
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Inouye, Michael
(author)
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Isomaa, Bo
(author)
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Johnson, Toby
(author)
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Kong, Augustine
(author)
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Krestyaninova, Maria
(author)
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Kuusisto, Johanna
(author)
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Laakso, Markku
(author)
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Lim, Noha
(author)
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Lindblad, UlfGothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xliulf
(author)
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Lindgren, Cecilia M.
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McCann, Owen T.
(author)
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Mohlke, Karen L.
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Morris, Andrew D.
(author)
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Naitza, Silvia
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Orru, Marco
(author)
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Palmer, Colin N. A.
(author)
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Pouta, Anneli
(author)
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Randall, Joshua
(author)
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Rathmann, Wolfgang
(author)
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Saramies, Jouko
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Scheet, Paul
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Scott, Laura J.
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Scuteri, Angelo
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Sharp, Stephen
(author)
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Sijbrands, Eric
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Smit, Jan H.
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Song, Kijoung
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Steinthorsdottir, Valgerdur
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Stringham, Heather M.
(author)
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Tuomi, Tiinamaija
(author)
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Tuomilehto, Jaakko
(author)
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Uitterlinden, Andre G.
(author)
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Voight, Benjamin F.
(author)
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Waterworth, Dawn
(author)
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Wichmann, H-Erich
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Willemsen, Gonneke
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Witteman, Jacqueline C. M.
(author)
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Yuan, Xin
(author)
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Zhao, Jing Hua
(author)
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Zeggini, Eleftheria
(author)
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Schlessinger, David
(author)
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Sandhu, Manjinder
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Boomsma, Dorret I.
(author)
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Uda, Manuela
(author)
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Spector, Tim D.
(author)
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Penninx, Brenda W. J. H.
(author)
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Altshuler, David
(author)
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Vollenweider, Peter
(author)
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Jarvelin, Marjo Riitta
(author)
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Lakatta, Edward
(author)
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Waeber, Gerard
(author)
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Fox, Caroline S.
(author)
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Peltonen, Leena
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Mooser, Vincent
(author)
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Cupples, L. Adrienne
(author)
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Thorsteinsdottir, Unnur
(author)
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Boehnke, Michael
(author)
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Barroso, Ines
(author)
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Van Duijn, Cornelia
(author)
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Dupuis, Josee
(author)
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Watanabe, Richard M.
(author)
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Stefansson, Kari
(author)
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McCarthy, Mark I.
(author)
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Wareham, Nicholas J.
(author)
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Meigs, James B.
(author)
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Abecasis, Goncalo R.
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC41:1, s. 77-811546-17181061-4036
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Prokopenko, Inga
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Langenberg, Clau ...
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Florez, Jose C.
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Saxena, Richa
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Soranzo, Nicole
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Thorleifsson, Gu ...
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show more...
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Loos, Ruth J. F.
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Manning, Alisa K ...
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Jackson, Anne U.
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Aulchenko, Yurii
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Potter, Simon C.
-
Erdos, Michael R ...
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Sanna, Serena
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Hottenga, Jouke- ...
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Wheeler, Eleanor
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Kaakinen, Marika
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Lyssenko, Valeri ...
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Chen, Wei-Min
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Ahmadi, Kourosh
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Beckmann, Jacque ...
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Bergman, Richard ...
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Bochud, Murielle
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Bonnycastle, Lor ...
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Buchanan, Thomas ...
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Cao, Antonio
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Cervino, Alessan ...
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Coin, Lachlan
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Collins, Francis ...
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Crisponi, Laura
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De Geus, Eco J. ...
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Dehghan, Abbas
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Deloukas, Panos
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Doney, Alex S. F ...
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Elliott, Paul
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Freimer, Nelson
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Gateva, Vesela
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Herder, Christia ...
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Hofman, Albert
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Hughes, Thomas E ...
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Hunt, Sarah
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Illig, Thomas
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Inouye, Michael
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Isomaa, Bo
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Johnson, Toby
-
Kong, Augustine
-
Krestyaninova, M ...
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Kuusisto, Johann ...
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Laakso, Markku
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Lim, Noha
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Lindblad, Ulf
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Lindgren, Cecili ...
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McCann, Owen T.
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Mohlke, Karen L.
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Morris, Andrew D ...
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Naitza, Silvia
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Orru, Marco
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Palmer, Colin N. ...
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Pouta, Anneli
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Randall, Joshua
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Rathmann, Wolfga ...
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Saramies, Jouko
-
Scheet, Paul
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Scott, Laura J.
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Scuteri, Angelo
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Sharp, Stephen
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Sijbrands, Eric
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Smit, Jan H.
-
Song, Kijoung
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Steinthorsdottir ...
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Stringham, Heath ...
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Tuomi, Tiinamaij ...
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Tuomilehto, Jaak ...
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Uitterlinden, An ...
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Voight, Benjamin ...
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Waterworth, Dawn
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Wichmann, H-Eric ...
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Willemsen, Gonne ...
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Witteman, Jacque ...
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Yuan, Xin
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Zhao, Jing Hua
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Zeggini, Elefthe ...
-
Schlessinger, Da ...
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Sandhu, Manjinde ...
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Boomsma, Dorret ...
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Uda, Manuela
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Spector, Tim D.
-
Penninx, Brenda ...
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Altshuler, David
-
Vollenweider, Pe ...
-
Jarvelin, Marjo ...
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Lakatta, Edward
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Waeber, Gerard
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Fox, Caroline S.
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Peltonen, Leena
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Groop, Leif
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Mooser, Vincent
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Cupples, L. Adri ...
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Thorsteinsdottir ...
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Boehnke, Michael
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Barroso, Ines
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Van Duijn, Corne ...
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Dupuis, Josee
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Watanabe, Richar ...
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Stefansson, Kari
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McCarthy, Mark I ...
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Wareham, Nichola ...
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Meigs, James B.
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Abecasis, Goncal ...
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