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Quantification of [...
Quantification of [18F]florbetaben amyloid-PET imaging in a mixed memory clinic population : The ABIDE project
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- Collij, Lyduine E. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Salvadó, Gemma (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Pasqual Maragall Foundation for Research on Alzheimer
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- de Wilde, Arno (author)
- Vrije Universiteit Amsterdam
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- Altomare, Daniele (author)
- Geneva University Hospital,University of Geneva
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- Shekari, Mahnaz (author)
- Pompeu Fabra University,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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- Gispert, Juan Domingo (author)
- Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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- Bullich, Santiago (author)
- Life Molecular Imaging GmbH
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- Stephens, Andrew (author)
- Life Molecular Imaging GmbH
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- Barkhof, Frederik (author)
- University College London
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- Scheltens, Philip (author)
- Vrije Universiteit Amsterdam
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- Bouwman, Femke (author)
- Vrije Universiteit Amsterdam
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- van der Flier, Wiesje M. (author)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2022-12-07
- 2023
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:6, s. 2397-2407
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Abstract
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- Introduction: We investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess the predictive value of visual read (VR) and CL on longitudinal Mini-Mental Status Examination (MMSE). Results: CL was associated with syndromic (F = 4.42, p = 0.014) and etiological diagnosis (F = -12.66, p < 0.001), with Alzheimer's disease (AD) patients showing the highest amyloid burden (62.9 ± 27.5), followed by dementia with Lewy bodies (DLB) (25.3 ± 35.5) and cardiovascular disease (CVD) (16.7 ± 24.5), and finally frontotemporal lobe degeneration (FTLD) (5.0 ± 17.22, t = –12.66, p < 0.001). CL remained predictive of etiological diagnosis (t = –2.41, p = 0.017) within the VR+ population (N = 157). VR was not a significant predictor of MMSE (t = –1.53, p = 0.13) for the SCD population (N = 90), whereas CL was (t = -3.30, p = 0.001). Discussion: The extent of amyloid pathology through quantification holds clinical value, potentially in the context of differential diagnosis as well as prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyloid-PET
- Centiloid quantification
- Dementia
- Diagnosis
- Prognosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Collij, Lyduine ...
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Salvadó, Gemma
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de Wilde, Arno
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Altomare, Daniel ...
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Shekari, Mahnaz
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Gispert, Juan Do ...
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show more...
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Bullich, Santiag ...
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Stephens, Andrew
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Barkhof, Frederi ...
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Scheltens, Phili ...
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Bouwman, Femke
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van der Flier, W ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University