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Clinical care advic...
Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes
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- Hendriks, A. Emile J. (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Marcovecchio, M. Loredana (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Besser, Rachel E.J. (author)
- University of Oxford
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- Bonifacio, Ezio (author)
- Dresden University of Technology,German Center for Diabetes Research
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- Casteels, Kristina (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Elding Larsson, Helena (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
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- Gemulla, Gita (author)
- Dresden University of Technology,University Clinic Carl Gustav Carus at the TU Dresden
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- Lundgren, Markus (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad
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Kordonouri, Olga (author)
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- Mallone, Roberto (author)
- Cochin Hospital,Institut Cochin
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- Pociot, Flemming (author)
- Steno Diabetes Center Copenhagen
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- Szypowska, Agnieszka (author)
- Medical University of Warsaw
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- Toppari, Jorma (author)
- University of Turku,Turku University Hospital
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Berge, Thekla von dem (author)
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- Ziegler, Anette G. (author)
- German Center for Diabetes Research,Klinikum rechts der Isar,Helmholtz Zentrum München
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- Mathieu, Chantal (author)
- University Hospitals Leuven
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- Achenbach, Peter (author)
- Helmholtz Zentrum München,Klinikum rechts der Isar,German Center for Diabetes Research
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Diabetes/Metabolism Research and Reviews. - 1520-7552. ; 40:2
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background/Aim: Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis. Methods: Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow-up strategies. Results: The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3-monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented. Conclusions: As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- monitoring
- presymptomatic type 1 diabetes
- primary care
- screening
- specialist care
- staging
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hendriks, A. Emi ...
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Marcovecchio, M. ...
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Besser, Rachel E ...
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Bonifacio, Ezio
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Casteels, Kristi ...
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Elding Larsson, ...
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show more...
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Gemulla, Gita
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Lundgren, Markus
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Kordonouri, Olga
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Mallone, Roberto
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Pociot, Flemming
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Szypowska, Agnie ...
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Toppari, Jorma
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Berge, Thekla vo ...
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Ziegler, Anette ...
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Mathieu, Chantal
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Achenbach, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes/Metabol ...
- By the university
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Lund University