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Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases
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- Ahuja-Jensen, Poonam (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups
- Johnsen-Soriano, Siv (author)
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- Ahuja, Satpal (author)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Bosch-Morell, Francisco (author)
- Sancho-Tello, Maria (author)
- Romero, Francisco Javier (author)
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- (creator_code:org_t)
- 2007
- 2007
- English.
- In: NeuroReport. - 1473-558X. ; 18:8, s. 797-801
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual inner retina also contribute to the oxidative stress and retinal degeneration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- retinal degeneration
- stress
- oxidative
- malondialdehyde
- cysteine protease
- glutathione system
- rd1 mice
Publication and Content Type
- art (subject category)
- ref (subject category)
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