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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

Thorsen, Steffen U (author)
University of Copenhagen
Liu, Xiang (author)
University of South Florida
Kataria, Yachana (author)
Boston University
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Mandrup-Poulsen, Thomas (author)
University of Copenhagen
Kaur, Simranjeet (author)
Copenhagen University Hospital
Uusitalo, Ulla (author)
University of South Florida
Virtanen, Suvi M (author)
Finnish National Institute for Health and Welfare
Norris, Jill M (author)
University of Colorado at Denver Anschutz Medical Campus
Rewers, Marian (author)
Pacific Northwest Research Institute
Hagopian, William (author)
University of Colorado-Denver
Yang, Jimin (author)
She, Jin-Xiong (author)
Akolkar, Beena (author)
Rich, Stephen (author)
Aronsson, Carin Andrén (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
Lernmark, Åke (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
Ziegler, Anette-Gabriele (author)
Toppari, Jorma (author)
Krischer, Jeffrey (author)
Parikh, Hemang M (author)
University of South Florida
Ellervik, Christina (author)
Svensson, Jannet (author)
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 (creator_code:org_t)
 
2023-03-03
2023
English.
In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 46:5, s. 1014-1018
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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