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Interaction Between...
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Thorsen, Steffen UUniversity of Copenhagen
(author)
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-03
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American Diabetes Association,2023
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:9a78c4f2-aa9c-48d2-b601-ab8b2baf0948
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https://lup.lub.lu.se/record/9a78c4f2-aa9c-48d2-b601-ab8b2baf0948URI
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https://doi.org/10.2337/dc22-1359DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Liu, XiangUniversity of South Florida
(author)
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Kataria, YachanaBoston University
(author)
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Mandrup-Poulsen, ThomasUniversity of Copenhagen
(author)
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Kaur, SimranjeetCopenhagen University Hospital
(author)
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Uusitalo, UllaUniversity of South Florida
(author)
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Virtanen, Suvi MFinnish National Institute for Health and Welfare
(author)
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Norris, Jill MUniversity of Colorado at Denver Anschutz Medical Campus
(author)
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Rewers, MarianPacific Northwest Research Institute
(author)
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Hagopian, WilliamUniversity of Colorado-Denver
(author)
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Yang, Jimin
(author)
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She, Jin-Xiong
(author)
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Akolkar, Beena
(author)
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Rich, Stephen
(author)
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Aronsson, Carin AndrénLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-can
(author)
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Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ale
(author)
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Ziegler, Anette-Gabriele
(author)
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Toppari, Jorma
(author)
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Krischer, Jeffrey
(author)
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Parikh, Hemang MUniversity of South Florida(Swepub:lu)he5472pa
(author)
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Ellervik, Christina
(author)
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Svensson, Jannet
(author)
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University of CopenhagenUniversity of South Florida
(creator_code:org_t)
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Environmental Determinants of Diabetes in the Young (TEDDY) Group
Related titles
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In:Diabetes Care: American Diabetes Association46:5, s. 1014-10181935-55480149-5992
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Thorsen, Steffen ...
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Liu, Xiang
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Kataria, Yachana
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Mandrup-Poulsen, ...
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Kaur, Simranjeet
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Uusitalo, Ulla
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Virtanen, Suvi M
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Norris, Jill M
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Rewers, Marian
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Hagopian, Willia ...
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Yang, Jimin
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She, Jin-Xiong
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Akolkar, Beena
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Rich, Stephen
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Aronsson, Carin ...
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Lernmark, Åke
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Ziegler, Anette- ...
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Toppari, Jorma
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Krischer, Jeffre ...
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Parikh, Hemang M
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Ellervik, Christ ...
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Svensson, Jannet
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Diabetes Care
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Lund University