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Assessment of Brain...
Assessment of Brain Injury and Brain Volumes after Posthemorrhagic Ventricular Dilatation : A Nested Substudy of the Randomized Controlled ELVIS Trial
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- Cizmeci, Mehmet N (author)
- University Medical Center Utrecht
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- Khalili, Nadieh (author)
- University Medical Center Utrecht
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- Claessens, Nathalie H P (author)
- University Medical Center Utrecht
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- Groenendaal, Floris (author)
- University Medical Center Utrecht
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- Liem, Kian D (author)
- Radboud University Medical Center
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- Heep, Axel (author)
- University of Bristol
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- Benavente-Fernández, Isabel (author)
- Puerta del Mar University Hospital
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- van Straaten, Henrica L M (author)
- Isala Women and Children's Hospital
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- van Wezel-Meijler, Gerda (author)
- Leiden University Medical Centre
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- Steggerda, Sylke J (author)
- Leiden University Medical Centre
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- Dudink, Jeroen (author)
- University Medical Center Utrecht
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- Išgum, Ivana (author)
- University Medical Center Utrecht
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- Whitelaw, Andrew (author)
- University of Bristol
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- Benders, Manon J N L (author)
- University Medical Center Utrecht
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- de Vries, Linda S (author)
- University Medical Center Utrecht
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- Ley, David (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups
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- Fellman, Vineta (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
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- Elsevier BV, 2019
- 2019
- English.
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In: Journal of Pediatrics. - : Elsevier BV. - 1097-6833 .- 0022-3476. ; 208, s. 2-197
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Abstract
Subject headings
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- OBJECTIVE: To compare the effect of early and late intervention for posthemorrhagic ventricular dilatation on additional brain injury and ventricular volume using term-equivalent age-MRI.STUDY DESIGN: In the Early vs Late Ventricular Intervention Study (ELVIS) trial, 126 preterm infants ≤34 weeks of gestation with posthemorrhagic ventricular dilatation were randomized to low-threshold (ventricular index >p97 and anterior horn width >6 mm) or high-threshold (ventricular index >p97 + 4 mm and anterior horn width >10 mm) groups. In 88 of those (80%) with a term-equivalent age-MRI, the Kidokoro Global Brain Abnormality Score and the frontal and occipital horn ratio were measured. Automatic segmentation was used for volumetric analysis.RESULTS: The total Kidokoro score of the infants in the low-threshold group (n = 44) was lower than in the high-threshold group (n = 44; median, 8 [IQR, 5-12] vs median 12 [IQR, 9-17], respectively; P < .001). More infants in the low-threshold group had a normal or mildly increased score vs more infants in the high-threshold group with a moderately or severely increased score (46% vs 11% and 89% vs 54%, respectively; P = .002). The frontal and occipital horn ratio was lower in the low-threshold group (median, 0.42 [IQR, 0.34-0.63]) than the high-threshold group (median 0.48 [IQR, 0.37-0.68], respectively; P = .001). Ventricular cerebrospinal fluid volumes could be calculated in 47 infants and were smaller in the low-threshold group (P = .03).CONCLUSIONS: More brain injury and larger ventricular volumes were demonstrated in the high vs the low-threshold group. These results support the positive effects of early intervention for posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Brain/diagnostic imaging
- Brain Injuries/diagnostic imaging
- Cerebral Hemorrhage/diagnostic imaging
- Cerebral Ventricles/diagnostic imaging
- Cerebrospinal Fluid
- Cerebrospinal Fluid Shunts
- Dilatation
- Female
- Humans
- Hydrocephalus/diagnostic imaging
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases/diagnostic imaging
- Intracranial Hemorrhages/diagnostic imaging
- Magnetic Resonance Imaging
- Male
- White Matter/diagnostic imaging
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Cizmeci, Mehmet ...
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Khalili, Nadieh
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Claessens, Natha ...
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Groenendaal, Flo ...
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Liem, Kian D
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Heep, Axel
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Benavente-Fernán ...
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van Straaten, He ...
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van Wezel-Meijle ...
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Steggerda, Sylke ...
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Dudink, Jeroen
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Išgum, Ivana
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Whitelaw, Andrew
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Benders, Manon J ...
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de Vries, Linda ...
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Ley, David
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Fellman, Vineta
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Pedia ...
- By the university
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Lund University