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Expression and moto...
Expression and motor effects of secretin in small and large intestine of the rat
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- Andersson, Amelie (author)
- Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups
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- Sundler, Frank (author)
- Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups
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- Ekblad, Eva (author)
- Lund University,Lunds universitet,Neurogastroenterologi,Forskargrupper vid Lunds universitet,Neurogastroenterology,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2000
- 2000
- English.
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In: Peptides. - : Elsevier BV. - 0196-9781. ; 21:11, s. 94-1687
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Immunocytochemistry and in situ hybridization revealed abundant secretin expressing cells on duodenal villi with a gradual decrease throughout the small intestines of the rat. They were absent in pancreas, stomach and colon. Secretin caused relaxation of rat intestinal longitudinal muscle in vitro. Studies on colon revealed that the secretin-evoked response was unaffected by apamin, tetrodotoxin, L-NAME, VIP or PACAP pretreatment; secretin itself caused desensitization. Addition of VIP or PACAP when the secretin-evoked relaxation was maximal evoked a further relaxation suggesting the presence of distinct receptors. Secretin causes relaxation via activation of secretin receptors located on the smooth muscle and not via any of the related VIP/PACAP receptors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Acetylcholine/pharmacology
- Animals
- Apamin/pharmacology
- Colon/drug effects
- Dose-Response Relationship, Drug
- Female
- Ganglia/metabolism
- Gastric Mucosa/metabolism
- Ileum/drug effects
- Immunohistochemistry
- In Situ Hybridization
- Intestine, Large/drug effects
- Intestine, Small/drug effects
- Muscle, Smooth/drug effects
- NG-Nitroarginine Methyl Ester/pharmacology
- Neuropeptides/pharmacology
- Neurotransmitter Agents/pharmacology
- Pancreas/metabolism
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Rats
- Rats, Sprague-Dawley
- Secretin/biosynthesis
- Tetrodotoxin/pharmacology
- Vasoactive Intestinal Peptide/pharmacology
Publication and Content Type
- art (subject category)
- ref (subject category)
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