Search: onr:"swepub:oai:lup.lub.lu.se:9c29cb8d-579b-41f9-9ca3-4b39d24519a7" >
Genome-wide associa...
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Newton-Cheh, Christopher
(author)
Genome-wide association study identifies eight loci associated with blood pressure
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-05-10
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Springer Science and Business Media LLC,2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:9c29cb8d-579b-41f9-9ca3-4b39d24519a7
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https://lup.lub.lu.se/record/1424819URI
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https://doi.org/10.1038/ng.361DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118831963URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129032URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
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Johnson, Toby
(author)
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Gateva, Vesela
(author)
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Tobin, Martin D.
(author)
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Bochud, Murielle
(author)
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Coin, Lachlan
(author)
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Najjar, Samer S.
(author)
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Zhao, Jing Hua
(author)
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Heath, Simon C.
(author)
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Eyheramendy, Susana
(author)
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Papadakis, Konstantinos
(author)
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Voight, Benjamin F.
(author)
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Scott, Laura J.
(author)
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Zhang, Feng
(author)
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Farrall, Martin
(author)
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Tanaka, Toshiko
(author)
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Wallace, Chris
(author)
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Chambers, John C.
(author)
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Khaw, Kay-Tee
(author)
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Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni
(author)
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van der Harst, Pim
(author)
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Polidoro, Silvia
(author)
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Grobbee, Diederick E.
(author)
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Onland-Moret, N. Charlotte
(author)
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Bots, Michiel L.
(author)
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Wain, Louise V.
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Elliott, Katherine S.
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Teumer, Alexander
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Luan, Jian'an
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Lucas, Gavin
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Kuusisto, Johanna
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Burton, Paul R.
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Hadley, David
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McArdle, Wendy L.
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Brown, Morris
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Dominiczak, Anna
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Newhouse, Stephen J.
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Samani, Nilesh J.
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Webster, John
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Zeggini, Eleftheria
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Beckmann, Jacques S.
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Bergmann, Sven
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Lim, Noha
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Song, Kijoung
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Vollenweider, Peter
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Waeber, Gerard
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Waterworth, Dawn M.
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Yuan, Xin
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor
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Allione, AlessandraKarolinska Institutet
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Di Gregorio, Alessandra
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Guarrera, Simonetta
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Panico, Salvatore
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Ricceri, Fulvio
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Romanazzi, Valeria
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Sacerdote, Carlotta
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Vineis, Paolo
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Barroso, Ines
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Sandhu, Manjinder S.
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Luben, Robert N.
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Stringham, Heather M.
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Valle, Timo T.
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Willer, Cristen J.
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Bergman, Richard N.
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Morken, Mario A.
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Doering, Angela
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Gieger, Christian
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Illig, Thomas
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Org, Elin
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Wichmann, H. Erich
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Kathiresan, Sekar
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O'Donnell, Christopher J.
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Schwartz, Stephen M.
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O'Reilly, Paul F.
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de Jong, Paul E.
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Hamsten, Anders
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Peden, John F.
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Seedorf, Udo
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Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva
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Tognoni, Giovanni
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Lakatta, Edward G.
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Sanna, Serena
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Scheet, Paul
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Schlessinger, David
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Scuteri, Angelo
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Doerr, Marcus
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Ernst, Florian
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Felix, Stephan B.
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Homuth, Georg
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Lorbeer, Roberto
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Reffelmann, Thorsten
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Gut, Ivo G.
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Zelenika, Diana
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Deloukas, Panos
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Soranzo, Nicole
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Williams, Frances M.
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Zhai, Guangju
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Salomaa, Veikko
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Elosua, Roberto
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Forouhi, Nita G.
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Uiterwaal, Cuno S.
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van der Schouw, Yvonne T.
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Numans, Mattijs E.
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Matullo, Giuseppe
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Navis, Gerjan
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Berglund, GöranLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-gbe
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Bingham, Sheila A.
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Connell, John M.
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Ferrucci, Luigi
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Watkins, Hugh
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Spector, Tim D.
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Strachan, David P.
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Laan, Maris
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Uda, Manuela
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Jarvelin, Marjo-Riitta
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Mooser, Vincent
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
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Loos, Ruth J. F.
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Abecasis, Goncalo R.
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Caulfield, Mark
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Munroe, Patricia B.
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Internmedicin - epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC41:6, s. 666-6761546-17181061-4036
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Newton-Cheh, Chr ...
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Johnson, Toby
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Gateva, Vesela
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Tobin, Martin D.
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Bochud, Murielle
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Coin, Lachlan
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Najjar, Samer S.
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Zhao, Jing Hua
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Heath, Simon C.
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Eyheramendy, Sus ...
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Papadakis, Konst ...
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Voight, Benjamin ...
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Scott, Laura J.
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Zhang, Feng
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Farrall, Martin
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Tanaka, Toshiko
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Wallace, Chris
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Chambers, John C ...
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Khaw, Kay-Tee
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Nilsson, Peter
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van der Harst, P ...
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Polidoro, Silvia
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Grobbee, Diederi ...
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Onland-Moret, N. ...
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Bots, Michiel L.
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Wain, Louise V.
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Elliott, Katheri ...
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Teumer, Alexande ...
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Luan, Jian'an
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Lucas, Gavin
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Kuusisto, Johann ...
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Burton, Paul R.
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Hadley, David
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McArdle, Wendy L ...
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Brown, Morris
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Dominiczak, Anna
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Newhouse, Stephe ...
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Samani, Nilesh J ...
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Webster, John
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Zeggini, Elefthe ...
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Beckmann, Jacque ...
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Bergmann, Sven
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Lim, Noha
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Song, Kijoung
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Vollenweider, Pe ...
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Waeber, Gerard
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Waterworth, Dawn ...
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Yuan, Xin
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Groop, Leif
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Orho-Melander, M ...
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Allione, Alessan ...
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Di Gregorio, Ale ...
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Guarrera, Simone ...
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Panico, Salvator ...
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Ricceri, Fulvio
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Romanazzi, Valer ...
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Sacerdote, Carlo ...
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Vineis, Paolo
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Barroso, Ines
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Sandhu, Manjinde ...
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Luben, Robert N.
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Crawford, Gabrie ...
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Jousilahti, Pekk ...
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Perola, Markus
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Boehnke, Michael
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Bonnycastle, Lor ...
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Collins, Francis ...
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Jackson, Anne U.
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Mohlke, Karen L.
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Stringham, Heath ...
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Valle, Timo T.
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Willer, Cristen ...
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Bergman, Richard ...
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Morken, Mario A.
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Doering, Angela
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Gieger, Christia ...
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Illig, Thomas
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Meitinger, Thoma ...
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Org, Elin
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Pfeufer, Arne
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Wichmann, H. Eri ...
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Kathiresan, Seka ...
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Marrugat, Jaume
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O'Donnell, Chris ...
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Schwartz, Stephe ...
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Siscovick, David ...
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Subirana, Isaac
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Freimer, Nelson ...
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Hartikainen, Ann ...
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McCarthy, Mark I ...
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O'Reilly, Paul F ...
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Peltonen, Leena
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Pouta, Anneli
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de Jong, Paul E.
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Snieder, Harold
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van Gilst, Wiek ...
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Clarke, Robert
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Goel, Anuj
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Hamsten, Anders
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Peden, John F.
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Seedorf, Udo
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Syvänen, Ann-Chr ...
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Tognoni, Giovann ...
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Lakatta, Edward ...
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Sanna, Serena
-
Scheet, Paul
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Schlessinger, Da ...
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Scuteri, Angelo
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Doerr, Marcus
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Ernst, Florian
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Felix, Stephan B ...
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Homuth, Georg
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Lorbeer, Roberto
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Reffelmann, Thor ...
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Rettig, Rainer
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Voelker, Uwe
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Galan, Pilar
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Gut, Ivo G.
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Hercberg, Serge
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Lathrop, G. Mark
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Zelenika, Diana
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Deloukas, Panos
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Soranzo, Nicole
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Williams, France ...
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Zhai, Guangju
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Salomaa, Veikko
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Laakso, Markku
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Elosua, Roberto
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Forouhi, Nita G.
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Volzke, Henry
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Uiterwaal, Cuno ...
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van der Schouw, ...
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Numans, Mattijs ...
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Matullo, Giusepp ...
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Navis, Gerjan
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Berglund, Göran
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Bingham, Sheila ...
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Kooner, Jaspal S ...
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Connell, John M.
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Bandinelli, Stef ...
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Ferrucci, Luigi
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Watkins, Hugh
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Spector, Tim D.
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Tuomilehto, Jaak ...
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Altshuler, David
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Strachan, David ...
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Laan, Maris
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Wareham, Nichola ...
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Uda, Manuela
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Jarvelin, Marjo- ...
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Mooser, Vincent
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Loos, Ruth J. F.
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