Genome-wide association study identifies eight loci associated with blood pressure

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MARC

Fältnamn	Indikatorer	Metadata
000		10575naa a2202317 4500
001		oai:lup.lub.lu.se:9c29cb8d-579b-41f9-9ca3-4b39d24519a7
003		SwePub
008		160401s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:118831963
009		oai:DiVA.org:uu-129032
024	7	a https://lup.lub.lu.se/record/14248192 URI
024	7	a https://doi.org/10.1038/ng.3612 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1188319632 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1290322 URI
040		a (SwePub)lud (SwePub)kid (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Newton-Cheh, Christopher4 aut
245	1 0	a Genome-wide association study identifies eight loci associated with blood pressure
264		c 2009-05-10
264	1	b Springer Science and Business Media LLC,c 2009
520		a Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a MEDICINE
700	1	a Johnson, Toby4 aut
700	1	a Gateva, Vesela4 aut
700	1	a Tobin, Martin D.4 aut
700	1	a Bochud, Murielle4 aut
700	1	a Coin, Lachlan4 aut
700	1	a Najjar, Samer S.4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a Heath, Simon C.4 aut
700	1	a Eyheramendy, Susana4 aut
700	1	a Papadakis, Konstantinos4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Scott, Laura J.4 aut
700	1	a Zhang, Feng4 aut
700	1	a Farrall, Martin4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Wallace, Chris4 aut
700	1	a Chambers, John C.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
700	1	a van der Harst, Pim4 aut
700	1	a Polidoro, Silvia4 aut
700	1	a Grobbee, Diederick E.4 aut
700	1	a Onland-Moret, N. Charlotte4 aut
700	1	a Bots, Michiel L.4 aut
700	1	a Wain, Louise V.4 aut
700	1	a Elliott, Katherine S.4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Lucas, Gavin4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Burton, Paul R.4 aut
700	1	a Hadley, David4 aut
700	1	a McArdle, Wendy L.4 aut
700	1	a Brown, Morris4 aut
700	1	a Dominiczak, Anna4 aut
700	1	a Newhouse, Stephen J.4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Webster, John4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Beckmann, Jacques S.4 aut
700	1	a Bergmann, Sven4 aut
700	1	a Lim, Noha4 aut
700	1	a Song, Kijoung4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Waeber, Gerard4 aut
700	1	a Waterworth, Dawn M.4 aut
700	1	a Yuan, Xin4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Allione, Alessandrau Karolinska Institutet4 aut
700	1	a Di Gregorio, Alessandra4 aut
700	1	a Guarrera, Simonetta4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Romanazzi, Valeria4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Barroso, Ines4 aut
700	1	a Sandhu, Manjinder S.4 aut
700	1	a Luben, Robert N.4 aut
700	1	a Crawford, Gabriel J.4 aut
700	1	a Jousilahti, Pekka4 aut
700	1	a Perola, Markus4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Bonnycastle, Lori L.4 aut
700	1	a Collins, Francis S.4 aut
700	1	a Jackson, Anne U.4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Stringham, Heather M.4 aut
700	1	a Valle, Timo T.4 aut
700	1	a Willer, Cristen J.4 aut
700	1	a Bergman, Richard N.4 aut
700	1	a Morken, Mario A.4 aut
700	1	a Doering, Angela4 aut
700	1	a Gieger, Christian4 aut
700	1	a Illig, Thomas4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Org, Elin4 aut
700	1	a Pfeufer, Arne4 aut
700	1	a Wichmann, H. Erich4 aut
700	1	a Kathiresan, Sekar4 aut
700	1	a Marrugat, Jaume4 aut
700	1	a O'Donnell, Christopher J.4 aut
700	1	a Schwartz, Stephen M.4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Subirana, Isaac4 aut
700	1	a Freimer, Nelson B.4 aut
700	1	a Hartikainen, Anna-Liisa4 aut
700	1	a McCarthy, Mark I.4 aut
700	1	a O'Reilly, Paul F.4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Pouta, Anneli4 aut
700	1	a de Jong, Paul E.4 aut
700	1	a Snieder, Harold4 aut
700	1	a van Gilst, Wiek H.4 aut
700	1	a Clarke, Robert4 aut
700	1	a Goel, Anuj4 aut
700	1	a Hamsten, Anders4 aut
700	1	a Peden, John F.4 aut
700	1	a Seedorf, Udo4 aut
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva
700	1	a Tognoni, Giovanni4 aut
700	1	a Lakatta, Edward G.4 aut
700	1	a Sanna, Serena4 aut
700	1	a Scheet, Paul4 aut
700	1	a Schlessinger, David4 aut
700	1	a Scuteri, Angelo4 aut
700	1	a Doerr, Marcus4 aut
700	1	a Ernst, Florian4 aut
700	1	a Felix, Stephan B.4 aut
700	1	a Homuth, Georg4 aut
700	1	a Lorbeer, Roberto4 aut
700	1	a Reffelmann, Thorsten4 aut
700	1	a Rettig, Rainer4 aut
700	1	a Voelker, Uwe4 aut
700	1	a Galan, Pilar4 aut
700	1	a Gut, Ivo G.4 aut
700	1	a Hercberg, Serge4 aut
700	1	a Lathrop, G. Mark4 aut
700	1	a Zelenika, Diana4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a Williams, Frances M.4 aut
700	1	a Zhai, Guangju4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Laakso, Markku4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Forouhi, Nita G.4 aut
700	1	a Volzke, Henry4 aut
700	1	a Uiterwaal, Cuno S.4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a Numans, Mattijs E.4 aut
700	1	a Matullo, Giuseppe4 aut
700	1	a Navis, Gerjan4 aut
700	1	a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe
700	1	a Bingham, Sheila A.4 aut
700	1	a Kooner, Jaspal S.4 aut
700	1	a Connell, John M.4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Watkins, Hugh4 aut
700	1	a Spector, Tim D.4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Altshuler, David4 aut
700	1	a Strachan, David P.4 aut
700	1	a Laan, Maris4 aut
700	1	a Meneton, Pierre4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Uda, Manuela4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Loos, Ruth J. F.4 aut
700	1	a Elliott, Paul4 aut
700	1	a Abecasis, Goncalo R.4 aut
700	1	a Caulfield, Mark4 aut
700	1	a Munroe, Patricia B.4 aut
710	2	a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 41:6, s. 666-676q 41:6<666-676x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.361y FULLTEXT
856	4	u https://www.pure.ed.ac.uk/ws/files/8320684/Genome_wide_association_study_identifies_eight_loci_associated_with_blood_pressure.pdf
856	4 8	u https://lup.lub.lu.se/record/1424819
856	4 8	u https://doi.org/10.1038/ng.361
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:118831963
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129032

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By the author/editor: Newton-Cheh, Chr ...; Johnson, Toby; Gateva, Vesela; Tobin, Martin D.; Bochud, Murielle; Coin, Lachlan; show more...; Najjar, Samer S.; Zhao, Jing Hua; Heath, Simon C.; Eyheramendy, Sus ...; Papadakis, Konst ...; Voight, Benjamin ...; Scott, Laura J.; Zhang, Feng; Farrall, Martin; Tanaka, Toshiko; Wallace, Chris; Chambers, John C ...; Khaw, Kay-Tee; Nilsson, Peter; van der Harst, P ...; Polidoro, Silvia; Grobbee, Diederi ...; Onland-Moret, N. ...; Bots, Michiel L.; Wain, Louise V.; Elliott, Katheri ...; Teumer, Alexande ...; Luan, Jian'an; Lucas, Gavin; Kuusisto, Johann ...; Burton, Paul R.; Hadley, David; McArdle, Wendy L ...; Brown, Morris; Dominiczak, Anna; Newhouse, Stephe ...; Samani, Nilesh J ...; Webster, John; Zeggini, Elefthe ...; Beckmann, Jacque ...; Bergmann, Sven; Lim, Noha; Song, Kijoung; Vollenweider, Pe ...; Waeber, Gerard; Waterworth, Dawn ...; Yuan, Xin; Groop, Leif; Orho-Melander, M ...; Allione, Alessan ...; Di Gregorio, Ale ...; Guarrera, Simone ...; Panico, Salvator ...; Ricceri, Fulvio; Romanazzi, Valer ...; Sacerdote, Carlo ...; Vineis, Paolo; Barroso, Ines; Sandhu, Manjinde ...; Luben, Robert N.; Crawford, Gabrie ...; Jousilahti, Pekk ...; Perola, Markus; Boehnke, Michael; Bonnycastle, Lor ...; Collins, Francis ...; Jackson, Anne U.; Mohlke, Karen L.; Stringham, Heath ...; Valle, Timo T.; Willer, Cristen ...; Bergman, Richard ...; Morken, Mario A.; Doering, Angela; Gieger, Christia ...; Illig, Thomas; Meitinger, Thoma ...; Org, Elin; Pfeufer, Arne; Wichmann, H. Eri ...; Kathiresan, Seka ...; Marrugat, Jaume; O'Donnell, Chris ...; Schwartz, Stephe ...; Siscovick, David ...; Subirana, Isaac; Freimer, Nelson ...; Hartikainen, Ann ...; McCarthy, Mark I ...; O'Reilly, Paul F ...; Peltonen, Leena; Pouta, Anneli; de Jong, Paul E.; Snieder, Harold; van Gilst, Wiek ...; Clarke, Robert; Goel, Anuj; Hamsten, Anders; Peden, John F.; Seedorf, Udo; Syvänen, Ann-Chr ...; Tognoni, Giovann ...; Lakatta, Edward ...; Sanna, Serena; Scheet, Paul; Schlessinger, Da ...; Scuteri, Angelo; Doerr, Marcus; Ernst, Florian; Felix, Stephan B ...; Homuth, Georg; Lorbeer, Roberto; Reffelmann, Thor ...; Rettig, Rainer; Voelker, Uwe; Galan, Pilar; Gut, Ivo G.; Hercberg, Serge; Lathrop, G. Mark; Zelenika, Diana; Deloukas, Panos; Soranzo, Nicole; Williams, France ...; Zhai, Guangju; Salomaa, Veikko; Laakso, Markku; Elosua, Roberto; Forouhi, Nita G.; Volzke, Henry; Uiterwaal, Cuno ...; van der Schouw, ...; Numans, Mattijs ...; Matullo, Giusepp ...; Navis, Gerjan; Berglund, Göran; Bingham, Sheila ...; Kooner, Jaspal S ...; Connell, John M.; Bandinelli, Stef ...; Ferrucci, Luigi; Watkins, Hugh; Spector, Tim D.; Tuomilehto, Jaak ...; Altshuler, David; Strachan, David ...; Laan, Maris; Meneton, Pierre; Wareham, Nichola ...; Uda, Manuela; Jarvelin, Marjo- ...; Mooser, Vincent; Melander, Olle; Loos, Ruth J. F.; Elliott, Paul; Abecasis, Goncal ...; Caulfield, Mark; Munroe, Patricia ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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