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Hematopoietic stem ...
Hematopoietic stem cell aging: Mechanism and consequence
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Rossi, Derrick J. (author)
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- Bryder, David (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Immunologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Immunology,Lund University Research Groups
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Weissman, Irving L. (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Experimental Gerontology. - : Elsevier BV. - 1873-6815 .- 0531-5565. ; 42:5, s. 385-390
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Abstract
Subject headings
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- Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- lineage
- myeloid
- lymphoid
- side population
- stem cell
- aging
- potential
- leukemia
Publication and Content Type
- art (subject category)
- ref (subject category)
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