Search: onr:"swepub:oai:lup.lub.lu.se:9c7e0f0f-7442-411e-a0c2-32bad59098b3" > SARS-CoV-2 Infectio...
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000 | 05980naa a2200529 4500 | |
001 | oai:lup.lub.lu.se:9c7e0f0f-7442-411e-a0c2-32bad59098b3 | |
003 | SwePub | |
008 | 230920s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/9c7e0f0f-7442-411e-a0c2-32bad59098b32 URI |
024 | 7 | a https://doi.org/10.1001/jama.2023.163482 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Lugar, Marijau Dresden University of Technology4 aut |
245 | 1 0 | a SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood |
264 | 1 | c 2023 |
300 | a 10 s. | |
520 | a IMPORTANCE: The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.OBJECTIVE: To determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.DESIGN, SETTING, AND PARTICIPANTS: Between February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.EXPOSURE: SARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.MAIN OUTCOMES AND MEASURES: The development of multiple (≥2) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.RESULTS: Consent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).CONCLUSION AND RELEVANCE: In young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Eugster, Anneu Dresden University of Technology4 aut |
700 | 1 | a Achenbach, Peteru Helmholtz Zentrum München,Technical University of Munich4 aut |
700 | 1 | a von dem Berge, Theklau Children's Hospital Auf der Bult4 aut |
700 | 1 | a Berner, Reinhardu University Clinic Carl Gustav Carus at the TU Dresden4 aut |
700 | 1 | a Besser, Rachel E Ju Oxford University Hospital4 aut |
700 | 1 | a Casteels, Kristinau Catholic University of Leuven,University Hospitals Leuven4 aut |
700 | 1 | a Elding Larsson, Helenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-hla |
700 | 1 | a Gemulla, Gitau University Clinic Carl Gustav Carus at the TU Dresden,Dresden University of Technology4 aut |
700 | 1 | a Kordonouri, Olgau Children's Hospital Auf der Bult4 aut |
700 | 1 | a Lindner, Annettu Dresden University of Technology4 aut |
700 | 1 | a Lundgren, Markusu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad4 aut0 (Swepub:lu)med-mn2 |
700 | 1 | a Müller, Deniseu Dresden University of Technology4 aut |
700 | 1 | a Oltarzewski, Mariuszu National Research Institute of Mother and Child4 aut |
700 | 1 | a Rochtus, Anneu University Hospitals Leuven,Catholic University of Leuven4 aut |
700 | 1 | a Scholz, Marlonu Technical University of Munich,Helmholtz Zentrum München4 aut |
700 | 1 | a Szypowska, Agnieszkau Medical University of Warsaw4 aut |
700 | 1 | a Todd, John Au University of Oxford4 aut |
700 | 1 | a Ziegler, Anette-Gabrieleu Technical University of Munich,Helmholtz Zentrum München4 aut |
700 | 1 | a Bonifacio, Eziou Dresden University of Technology,Helmholtz Zentrum München,University Clinic Carl Gustav Carus at the TU Dresden4 aut |
710 | 2 | a Dresden University of Technologyb Helmholtz Zentrum München4 org |
710 | 2 | a GPPAD Study Group |
773 | 0 | t JAMAg 330:12q 330:12x 0098-7484 |
856 | 4 | u http://dx.doi.org/10.1001/jama.2023.16348y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/9c7e0f0f-7442-411e-a0c2-32bad59098b3 |
856 | 4 8 | u https://doi.org/10.1001/jama.2023.16348 |
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