Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

Iversen, AKN (author)

Christiansen, CB (author)

Attermann, J (author)

Eugen-Olsen, J (author)

Schulman, S (author)

Berntorp, Erik (author): Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups

Ingerslev, J (author)

Fugger, L (author)

Scheibel, E (author)

Tengborn, Lilian (author): Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Coagulation, Malmö,Lund University Research Groups

Gerstoft, J (author)

Dickmeiss, E (author)

Svejgaard, A (author)

Skinhoj, P (author)

(creator_code:org_t)

Related links:: http://ucp.uchicago....; show more...; https://lup.lub.lu.s...; show less...

Abstract Subject headings

The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.

By the author/editor: Iversen, AKN; Christiansen, CB; Attermann, J; Eugen-Olsen, J; Schulman, S; Berntorp, Erik; show more...; Ingerslev, J; Fugger, L; Scheibel, E; Tengborn, Lilian; Gerstoft, J; Dickmeiss, E; Svejgaard, A; Skinhoj, P; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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