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Randomized, Multice...
Randomized, Multicenter, Phase II Study of CO-101 Versus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma: Including a Prospective Evaluation of the Role of hENT1 in Gemcitabine or CO-101 Sensitivity.
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Poplin, Elizabeth (author)
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Wasan, Harpreet (author)
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Rolfe, Lindsey (author)
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Raponi, Mitch (author)
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Ikdahl, Tone (author)
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Bondarenko, Ihor (author)
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Davidenko, Irina (author)
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Bondar, Volodymyr (author)
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Garin, August (author)
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Boeck, Stefan (author)
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Ormanns, Steffen (author)
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Heinemann, Volker (author)
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Bassi, Claudio (author)
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Evans, T R Jeffrey (author)
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- Andersson, Roland (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Hahn, Hejin (author)
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Picozzi, Vince (author)
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Dicker, Adam (author)
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Mann, Elaina (author)
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Voong, Cynthia (author)
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Kaur, Paramjit (author)
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Isaacson, Jeff (author)
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Allen, Andrew (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Journal of Clinical Oncology. - 1527-7755. ; 31:35, s. 4453-4461
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Gemcitabine requires transporter proteins to cross cell membranes. Low expression of human equilibrative nucleoside transporter-1 (hENT1) may result in gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). CO-101, a lipid-drug conjugate of gemcitabine, was rationally designed to enter cells independently of hENT1. We conducted a randomized controlled trial to determine whether CO-101 improved survival versus gemcitabine in patients with metastatic PDAC (mPDAC) with low hENT1. The study also tested the hypothesis that gemcitabine is more active in patients with mPDAC tumors with high versus low hENT1 expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Poplin, Elizabet ...
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Wasan, Harpreet
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Rolfe, Lindsey
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Raponi, Mitch
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Ikdahl, Tone
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Bondarenko, Ihor
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show more...
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Davidenko, Irina
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Bondar, Volodymy ...
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Garin, August
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Boeck, Stefan
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Ormanns, Steffen
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Heinemann, Volke ...
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Bassi, Claudio
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Evans, T R Jeffr ...
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Andersson, Rolan ...
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Hahn, Hejin
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Picozzi, Vince
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Dicker, Adam
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Mann, Elaina
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Voong, Cynthia
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Kaur, Paramjit
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Isaacson, Jeff
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Allen, Andrew
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Clini ...
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Lund University