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Timing of Puberty, ...
Timing of Puberty, Pubertal Growth, and Adult Height in Short Children Born Small for Gestational Age Treated With Growth Hormone
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- Upners, Emmie N. (author)
- Copenhagen University Hospital
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- Raket, Lars Lau (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Petersen, Jørgen H. (author)
- Copenhagen University Hospital
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- Thankamony, Ajay (author)
- University of Cambridge
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- Roche, Edna (author)
- Tallaght University Hospital
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- Shaikh, Guftar (author)
- Royal Hospital for Sick Children, Glasgow
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- Kirk, Jeremy (author)
- Birmingham Children's Hospital
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- Hoey, Hilary (author)
- Tallaght University Hospital
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- Ivarsson, Sten A. (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Pediatrisk endokrinologi,Celiac Disease and Diabetes Unit,Lund University Research Groups,Paediatric Endocrinology
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- Soder, Olle (author)
- Karolinska Institute
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- Juul, Anders (author)
- University of Copenhagen,Copenhagen University Hospital
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- Jensen, Rikke Beck (author)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2022-05-06
- 2022
- English 10 s.
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:8, s. 2286-2295
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Abstract
Subject headings
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- Context: Growth hormone (GH) is used to treat short children born small for gestational age (SGA); however, the effects of treatment on pubertal timing and adult height are rarely studied. Objective: To evaluate adult height and peak height velocity in short GH-treated SGA children. Methods: Prospective longitudinal multicenter study. Participants were short children born SGA treated with GH therapy (n = 102). Adult height was reported in 47 children. A reference cohort of Danish children was used. Main outcome measures were adult height, peak height velocity, age at peak height, and pubertal onset. Pubertal onset was converted to SD score (SDS) using Danish reference data. Results: Gain in height SDS from start of treatment until adult height was significant in both girls (0.94 [0.75; 1.53] SDS, P = .02) and boys (1.57 [1.13; 2.15] SDS, P < .001). No difference in adult height between GH dosage groups was observed. Peak height velocity was lower than a reference cohort for girls (6.5 [5.9; 7.6] cm/year vs 7.9 [7.4; 8.5] cm/year, P < .001) and boys (9.5 [8.4; 10.7] cm/year vs 10.1 [9.7; 10.7] cm/year, P = .002), but no difference in age at peak height velocity was seen. Puberty onset was earlier in SGA boys than a reference cohort (1.06 [-0.03; 1.96] SDS vs 0 SDS, P = .002) but not in girls (0.38 [-0.19; 1.05] SDS vs 0 SDS, P = .18). Conclusion: GH treatment improved adult height. Peak height velocity was reduced, but age at peak height velocity did not differ compared with the reference cohort. SGA boys had an earlier pubertal onset compared with the reference cohort.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- adult height
- GH treatment
- peak height velocity
- puberty
- SGA
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Upners, Emmie N.
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Raket, Lars Lau
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Petersen, Jørgen ...
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Thankamony, Ajay
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Roche, Edna
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Shaikh, Guftar
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show more...
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Kirk, Jeremy
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Hoey, Hilary
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Ivarsson, Sten A ...
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Soder, Olle
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Juul, Anders
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Jensen, Rikke Be ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Lund University
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Karolinska Institutet