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Gut microbiota comp...
Gut microbiota composition is altered in postural orthostatic tachycardia syndrome and post-acute COVID-19 syndrome
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- Hamrefors, Viktor (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Kahn, Fredrik (author)
- Lund University,Lunds universitet,Neutrofiler – nya mekanismer och nya markörer,Forskargrupper vid Lunds universitet,Neutrophils – new mechanisms and new biomarkers,Lund University Research Groups,Skåne University Hospital
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- Holmqvist, Madlene (author)
- Lund University,Lunds universitet,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Translational Sepsis research,Lund University Research Groups,Skåne University Hospital
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- Carlson, Katherine (author)
- Lund University,Lunds universitet,Neutrofiler – nya mekanismer och nya markörer,Forskargrupper vid Lunds universitet,Neutrophils – new mechanisms and new biomarkers,Lund University Research Groups,Skåne University Hospital
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- Varjus, Roosa (author)
- Clinical Microbiomics
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- Gudjonsson, Alexander (author)
- Clinical Microbiomics
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- Fedorowski, Artur (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Scientific Reports. - 2045-2322. ; 14:1
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Abstract
Subject headings
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- Postural Orthostatic Tachycardia Syndrome (POTS) reflects an autonomic dysfunction, which can occur as a complication to COVID-19. Our aim was to examine gastrointestinal symptoms and gut microbiota composition in patients with POTS and post-acute COVID-19 syndrome (PACS), compared with controls. POTS patients (n = 27), PACS patients (n = 32) and controls (n = 39) delivered fecal samples and completed a 4-day food diary, irritable bowel syndrome-severity scoring system (IBS-SSS), and visual analog scale for IBS (VAS-IBS). A total of 98 DNA aliquots were sequenced to an average depth of 28.3 million (M) read pairs (Illumina 2 × 150 PE) per sample. Diversity and taxonomic levels of the microbiome, as well as functional abundances were calculated for POTS and PACS groups, then compared with controls. There were several differences in taxonomic composition between POTS and controls, whereas only the abundance of Ascomycota and Firmicutes differed between PACS and controls. The clinical variables total IBS-SSS, fatigue, and bloating and flatulence significantly correlated with multiple individual taxa abundances, alpha diversity, and functional abundances. We conclude that POTS, and to a less extent PACS, are associated with differences in gut microbiota composition in diversity and at several taxonomic levels. Clinical symptoms are correlated with both alpha diversity and taxonomic and functional abundances.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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