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- Kozakova, M. (author)
Gender-specific differences in carotid intima-media thickness and its progression over three years: A multicenter European study
- Article/chapterEnglish2013
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- Elsevier BV,2013
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- LIBRIS-ID:oai:lup.lub.lu.se:9d6a3a25-e11d-4f97-9a97-36d22c4f39f6
- https://lup.lub.lu.se/record/3580914URI
- https://doi.org/10.1016/j.numecd.2011.04.006DOI
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- Language:English
- Summary in:English
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- Background and aims: This multicentre European study evaluated, in a young-to-middle-aged healthy population without carotid atherosclerosis, the gender-related differences in carotid intima-media thickness (IMT) and its short-term (3-year) progression, and whether these differences are related to different vascular ageing rate, cardiovascular risk profile or different susceptibility to family predisposition to cardiovascular diseases (CVD). Methods and results: 366 men and 422 women (age between 30 and 60 years) underwent B-mode carotid ultrasound at baseline and after 3-year follow-up period. IMT in 3 carotid segments was higher in men than in women (p < 0.0001 for all segments). When evaluated according to age decade, differences between men and women disappeared in the 6th decade, as in this decade a 3-year IMT progression rate accelerated in women (p < 0.05 as compared to the 4th and 5th age decade). Age was a major determinant of baseline all-segment IMT in women; in men all-segment IMT was influenced by age and LDL-cholesterol. IMT progression did not correlate with established cardiovascular risk factors, their short-term changes or family predisposition to CVD. Yet, a 3-year IMT progression in common carotid artery (CCA) was higher in men (p = 0.01) and women (p < 0.01) in whom relative Framingham risk increased during the corresponding period. Conclusion: This study provides reference values on IMT and its short-term progression in healthy young-to-middle-aged population, and demonstrates gender-related differences in the susceptibility of carotid wall to ageing and LDL-cholesterol. Increase in Framingham risk accelerated a short-term CCA IMT progression rate in both genders, whereas family predisposition to CVD did not influence carotid IMT. (C) 2011 Elsevier B. V. All rights reserved.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Carotid ultrasound
- Gender
- Menopause
- Risk factors
- Vascular ageing
Added entries (persons, corporate bodies, meetings, titles ...)
- Palombo, C. (author)
- Morizzo, C. (author)
- Nolan, J. J. (author)
- Konrad, T. (author)
- Dekker, J. M. (author)
- Balkau, B. (author)
- Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
- Internmedicin - epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:Nutrition Metabolism and Cardiovascular Diseases: Elsevier BV23:2, s. 151-1581590-37290939-4753
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