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Successful aging : Insights from proteome analyses of healthy centenarians

Santos-Lozano, Alejandro (author)
European University Miguel de Cervantes,12 de Octubre University Hospital
Valenzuela, Pedro L. (author)
University of Alcalá
Llavero, Francisco (author)
Achucarro - Basque Center for Neuroscience
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Lista, Simone (author)
Pitié-Salpêtrière University Hospital,Paris-Sorbonne University,Brain and Spine Institute (ICM)
Carrera-Bastos, Pedro (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research,NutriScience-Education and Consulting,Skåne University Hospital
Hampel, Harald (author)
Paris-Sorbonne University
Pareja-Galeano, Helios (author)
European University of Madrid
Gálvez, Beatriz G. (author)
European University of Madrid
López, Juan Antonio (author)
Centro Nacional de Investigaciones Cardiovasculares Carlos III,Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
Vázquez, Jesús (author)
Centro Nacional de Investigaciones Cardiovasculares Carlos III,Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
Emanuele, Enzo (author)
2E Science
Zugaza, José L. (author)
University of the Basque Country,Achucarro - Basque Center for Neuroscience,Basque Foundation for Science
Lucia, Alejandro (author)
European University of Madrid,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),European University Miguel de Cervantes
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 (creator_code:org_t)
2020-02-25
2020
English.
In: Aging. - : Impact Journals, LLC. - 1945-4589. ; 12:4, s. 3502-3515
Related links:
http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Elderly
Healthy aging
Immune system
Proteomics
Senescence

Publication and Content Type

art (subject category)
ref (subject category)

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