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Reactivity of anti-PSA monoclonal antibodies with recombinant human kallikrein-2
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- Leinonen, J. (author)
- Helsinki University Central Hospital
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- Leinimaa, M. (author)
- Helsinki University Central Hospital
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- Zhang, W. M. (author)
- Helsinki University Central Hospital
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 1999
- 1999
- English.
- In: Tumor Biology. - : Springer Science and Business Media LLC. - 1010-4283 .- 1423-0380. ; 20:SUPPL. 1, s. 35-37
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Seventy-nine monoclonal antibodies submitted to the ISOBM TD-3 PSA Workshop were tested for their reactivity with recombinant human kallikrein-2 (rhK2). A sandwich immunofluorometric assay using polyclonal antiprostate- specific antigen (PSA) antiserum-coated plates was used to capture rhK2 and subsequently the test antibody. The response of each test antibody was compared with 3 reference antibodies (H50, H117 and 5E4) known to react with hK2. Nine antibodies from the workshop panel failed to react with purified PSA and rhK2 in this assay and were subsequently excluded. From the remaining panel of antibodies, 11/70 showed strong reactivity with rhK2, 9/70 showed weak reactivity with rhK2, while 50/70 antibodies did not react with rhK2 in this assay format. All antibodies binding to rhK2 recognized both free and complexed PSA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Human kallikrein-2
- ISOBM
- Monoclonal antibodies
- Prostate-specific antigen
- Recombinant kallikrein
- TD-3
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Leinonen, J.
- Leinimaa, M.
- Zhang, W. M.
- Piironen, T.
- Pettersson, K.
- Lilja, H.
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- Dowell, B.
- Stenman, U. H.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- Tumor Biology
- By the university
- Lund University
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