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Effect of Cyclospor...
Effect of Cyclosporine on Cytokine Production in Elective Coronary Artery Bypass Grafting : A Sub-Analysis of the CiPRICS (Cyclosporine to Protect Renal Function in Cardiac Surgery) Study
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- Grins, Edgars (author)
- Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Thoraxanestesi och intensivvård,Less invasive cardiac surgery,Lund University Research Groups,Cardiothoracic anesthesia and intensive care,Skåne University Hospital
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- Ederoth, Per (author)
- Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Thoraxanestesi och intensivvård,Less invasive cardiac surgery,Lund University Research Groups,Cardiothoracic anesthesia and intensive care,Skåne University Hospital
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- Bjursten, Henrik (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Less invasive cardiac surgery,Lund University Research Groups,Skåne University Hospital
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- Dardashti, Alain (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Less invasive cardiac surgery,Lund University Research Groups,Skåne University Hospital
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- Brondén, Björn (author)
- Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Thoraxanestesi och intensivvård,Less invasive cardiac surgery,Lund University Research Groups,Cardiothoracic anesthesia and intensive care,Skåne University Hospital
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- Metzsch, Carsten (author)
- Lund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,Thoraxanestesi och intensivvård,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Less invasive cardiac surgery,Cardiothoracic anesthesia and intensive care,Skåne University Hospital
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- Erdling, André (author)
- Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Neurovaskulär forskning,Less invasive cardiac surgery,Lund University Research Groups,Applied Neurovascular Research,Skåne University Hospital
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- Nozohoor, Shahab (author)
- Lund University,Lunds universitet,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Bleeding disorders and acute typ-A dissection,Skåne University Hospital
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- Mokhtari, Arash (author)
- Lund University,Lunds universitet,NPWT teknologin,Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,NPWT technology,Lund University Research Groups,Less invasive cardiac surgery,Skåne University Hospital
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- Hansson, Magnus J. (author)
- Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
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- Elmér, Eskil (author)
- Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
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- Algotsson, Lars (author)
- Lund University,Lunds universitet,Klinisk och experimentell lungtransplantation,Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,Thoraxanestesi och intensivvård,Clinical and experimental lung transplantation,Lund University Research Groups,Less invasive cardiac surgery,Cardiothoracic anesthesia and intensive care,Skåne University Hospital
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- Shrestha, Nabin Manandhar (author)
- Van Andel Research Institute
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- Jovinge, Stefan (author)
- Stanford University,Van Andel Research Institute
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Journal of Cardiothoracic and Vascular Anesthesia. - : Elsevier BV. - 1053-0770. ; 36:7, s. 1985-1994
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Abstract
Subject headings
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- Objectives: The augmented inflammatory response to cardiac surgery is a recognized cause of postoperative acute kidney injury. The present study aimed to investigate the effects of preoperative cyclosporine treatment on cytokine production and delineate factors associated with postoperative kidney impairment. Design: A randomized, double-blind, placebo-controlled, single-center study. Setting: At a tertiary care, university hospital. Participants: Patients eligible for elective coronary artery bypass grafting surgery; 67 patients were enrolled. Interventions: Patients were randomized to receive 2.5 mg/kg cyclosporine or placebo before surgery. Cytokine levels were measured after the induction of anesthesia and 4 hours after the end of cardiopulmonary bypass. Measurements and Main Results: Tissue-aggressive (interleukin [IL]-1β, macrophage inflammatory protein [MIP]-1β, granulocyte colony-stimulating factor [G-CSF], IL-6, IL-8, IL-17, MCP-1), as well tissue-lenient (IL-4) cytokines, were significantly elevated in response to surgery. Changes in cytokine levels were not affected by cyclosporine pretreatment. Conclusions: Elective coronary artery bypass grafting surgery with cardiopulmonary bypass triggers cytokine activation. This activation was not impacted by preoperative cyclosporine treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- acute kidney injury
- cardiac surgery
- cyclosporine
- cystatin C
- cytokines, IL-6
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Grins, Edgars
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Ederoth, Per
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Bjursten, Henrik
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Dardashti, Alain
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Brondén, Björn
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Metzsch, Carsten
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Erdling, André
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Nozohoor, Shahab
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Mokhtari, Arash
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Hansson, Magnus ...
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Elmér, Eskil
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Algotsson, Lars
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Shrestha, Nabin ...
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Jovinge, Stefan
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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Lund University