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  • Eendebak, Robert J A HUniversity of Manchester (author)

The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016
  • 11 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9ed84d39-a171-4364-836e-cb92b67c02b7
  • https://lup.lub.lu.se/record/9ed84d39-a171-4364-836e-cb92b67c02b7URI
  • https://doi.org/10.1530/EJE-16-0447DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Huhtaniemi, Ilpo T.Imperial College London (author)
  • Pye, Stephen R.University of Manchester (author)
  • Ahern, TomasUniversity of Manchester (author)
  • W O'Neill, TerenceUniversity of Manchester (author)
  • Bartfai, GyörgyUniversity of Szeged (author)
  • Casanueva, Felipe F.University of Santiago de Compostela (author)
  • Maggi, MarioUniversity of Florence (author)
  • Forti, GianniUniversity of Florence (author)
  • Alston, Robert D.University of Manchester (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-agi (author)
  • Han, Thang S.University College London (author)
  • Kula, KrzysztofMedical University of Lodz (author)
  • Lean, Michael E JUniversity of Glasgow (author)
  • Punab, MargusUniversity of Tartu (author)
  • Pendleton, NeilUniversity of Manchester (author)
  • Keevil, Brian G.University Hospital of South Manchester NHS Foundation Trust (author)
  • Vanderschueren, DirkCatholic University of Leuven (author)
  • Rutter, Martin K.Manchester University NHS Foundation Trust,University of Manchester (author)
  • Tampubolon, GindoUniversity of Manchester (author)
  • Goodacre, RoystonUniversity of Manchester (author)
  • Wu, Frederick C WUniversity of Manchester (author)
  • University of ManchesterImperial College London (creator_code:org_t)

Related titles

  • In:European Journal of Endocrinology175:6, s. 583-5930804-4643

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