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The androgen recept...
The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men
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- Eendebak, Robert J A H (author)
- University of Manchester
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- Huhtaniemi, Ilpo T. (author)
- Imperial College London
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- Pye, Stephen R. (author)
- University of Manchester
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- Ahern, Tomas (author)
- University of Manchester
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- W O'Neill, Terence (author)
- University of Manchester
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- Bartfai, György (author)
- University of Szeged
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- Casanueva, Felipe F. (author)
- University of Santiago de Compostela
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- Maggi, Mario (author)
- University of Florence
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- Forti, Gianni (author)
- University of Florence
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- Alston, Robert D. (author)
- University of Manchester
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital
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- Han, Thang S. (author)
- University College London
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- Kula, Krzysztof (author)
- Medical University of Lodz
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- Lean, Michael E J (author)
- University of Glasgow
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- Punab, Margus (author)
- University of Tartu
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- Pendleton, Neil (author)
- University of Manchester
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- Keevil, Brian G. (author)
- University Hospital of South Manchester NHS Foundation Trust
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- Vanderschueren, Dirk (author)
- Catholic University of Leuven
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- Rutter, Martin K. (author)
- Manchester University NHS Foundation Trust,University of Manchester
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- Tampubolon, Gindo (author)
- University of Manchester
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- Goodacre, Royston (author)
- University of Manchester
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- Wu, Frederick C W (author)
- University of Manchester
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(creator_code:org_t)
- 2016
- 2016
- English 11 s.
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In: European Journal of Endocrinology. - 0804-4643. ; 175:6, s. 583-593
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Eendebak, Robert ...
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Huhtaniemi, Ilpo ...
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Pye, Stephen R.
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Ahern, Tomas
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W O'Neill, Teren ...
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Bartfai, György
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show more...
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Casanueva, Felip ...
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Maggi, Mario
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Forti, Gianni
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Alston, Robert D ...
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Giwercman, Aleks ...
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Han, Thang S.
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Kula, Krzysztof
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Lean, Michael E ...
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Punab, Margus
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Pendleton, Neil
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Keevil, Brian G.
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Vanderschueren, ...
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Rutter, Martin K ...
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Tampubolon, Gind ...
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Goodacre, Roysto ...
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Wu, Frederick C ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University