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Assessment of the a...
Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort : The ABIDE project
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- de Wilde, Arno (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Pelkmans, Wiesje (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Bouwman, Femke (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Groot, Colin (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- van Maurik, Ingrid (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Zwan, Marissa (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Yaqub, Maqsood (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Barkhof, Frederik (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University College London,Vrije Universiteit Amsterdam
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- Lammertsma, Adriaan A. (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Biessels, Geert Jan (author)
- University Medical Center Utrecht
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- van Berckel, Bart N. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- van der Flier, Wiesje M. (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2019-10-06
- 2019
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260.
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Abstract
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- Introduction: The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. Methods: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in post–positron emission tomography diagnosis and management change between “AUC-consistent” and “AUC-inconsistent” patients. Results: Almost half (250/507) of patients were AUC-consistent. In both AUC-consistent and AUC-inconsistent patients, post–positron emission tomography diagnosis (28%–21%) and management (32%–17%) change was substantial. The Amyloid Imaging Taskforce's definition of appropriate use occurred in 55/507 (13%) patients, detected by the AUC with a sensitivity of 93%, and a specificity of 56%. Diagnostic changes occurred independently of AUC status (sensitivity: 57%, specificity: 53%). Discussion: The current AUC are not sufficiently able to discriminate between patients who will benefit from amyloid positron emission tomography and those who will not.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid
- Appropriate use criteria
- Clinical practice
- Dementia
- Positron emission tomography
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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de Wilde, Arno
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Ossenkoppele, Ri ...
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Pelkmans, Wiesje
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Bouwman, Femke
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Groot, Colin
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van Maurik, Ingr ...
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show more...
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Zwan, Marissa
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Yaqub, Maqsood
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Barkhof, Frederi ...
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Lammertsma, Adri ...
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Biessels, Geert ...
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Scheltens, Phili ...
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van Berckel, Bar ...
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van der Flier, W ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University