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One evidence base; ...
One evidence base; three stories : do opioids relieve chronic breathlessness?
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- Ekström, Magnus (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Breathlessness and chronic respiratory failure,Lund University Research Groups
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- Bajwah, Sabrina (author)
- King's College London
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- Bland, J. Martin (author)
- University of York
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- Currow, David C. (author)
- Flinders University
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- Hussain, Jamilla (author)
- Hull York Medical School
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- Johnson, Miriam J. (author)
- Hull York Medical School
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(creator_code:org_t)
- 2017-04-04
- 2018
- English 3 s.
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In: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 73:1, s. 88-90
- Related links:
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http://dx.doi.org/10...
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https://thorax.bmj.c...
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Abstract
Subject headings
Close
- The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- COPD Pharmacology
- Palliative Care
- Perception of Asthma/Breathlessness
Publication and Content Type
- art (subject category)
- ref (subject category)
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