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Search: onr:"swepub:oai:lup.lub.lu.se:9f3aa9fd-f216-42c1-9533-f1717c9765d6" > Profiles of Glucose...

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  • Tura, AndreaCNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC),CNR Inst Neurosci, Padua, Italy. (author)

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-07-07
  • American Diabetes Association,2021
  • 15 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9f3aa9fd-f216-42c1-9533-f1717c9765d6
  • https://lup.lub.lu.se/record/9f3aa9fd-f216-42c1-9533-f1717c9765d6URI
  • https://doi.org/10.2337/db21-0227DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-304065URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • QC 20211027
  • Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Grespan, EleonoraCNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC) (author)
  • Göbl, Christian S.Medical University of Vienna (author)
  • Koivula, Robert W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,University of Oxford(Swepub:lu)med-rkl (author)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-plf (author)
  • Pearson, Ewan R.University of Dundee(Swepub:lu)ew1481pe (author)
  • Walker, MarkUniversity of Newcastle upon Tyne (author)
  • Forgie, Ian M.University of Dundee (author)
  • Giordano, Giuseppe N.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-geg (author)
  • Pavo, ImreEli Lilly Regional Operations G.m.b.H. (author)
  • Ruetten, HartmutBoehringer Ingelheim GmbH (author)
  • Dermitzakis, Emmanouil T.University of Geneva Medical School (author)
  • McCarthy, Mark I.University of Oxford (author)
  • Pedersen, OlufUniversity of Copenhagen (author)
  • Schwenk, Jochen M.KTH,KTH Royal Institute of Technology,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1h7wtme (author)
  • Adamski, JerzyNational University of Singapore,University of Ljubljana,Helmholtz Zentrum München (author)
  • De Masi, FedericoTechnical University of Denmark,University of Copenhagen (author)
  • Tsirigos, Konstantinos D.Technical University of Denmark,University of Copenhagen (author)
  • Brunak, SørenUniversity of Copenhagen,Technical University of Denmark (author)
  • Viñuela, AnaUniversity of Geneva Medical School,University of Newcastle upon Tyne (author)
  • Mahajan, AnubhaWellcome Trust Centre for Human Genetics (author)
  • McDonald, Timothy J.Royal Devon and Exeter NHS Foundation Trust (author)
  • Kokkola, TarjaUniversity of Eastern Finland (author)
  • Vangipurapu, JagadishUniversity of Eastern Finland (author)
  • Cederberg, HennaUniversity of Eastern Finland (author)
  • Laakso, MarkkuUniversity of Eastern Finland (author)
  • Rutters, FemkeAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Elders, Petra J.M.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Koopman, Anitra D.M.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Beulens, Joline W.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Ridderstråle, MartinLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)endo-mri (author)
  • Hansen, Tue H.University of Copenhagen (author)
  • Allin, Kristine H.University of Copenhagen (author)
  • Hansen, TorbenUniversity of Copenhagen (author)
  • Vestergaard, HenrikUniversity of Copenhagen,Bornholms Hospital (author)
  • Mari, AndreaCNR Institute of Neuroscience, Pisa,CNR Inst Neurosci, Padua, Italy. (author)
  • CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC)CNR Inst Neurosci, Padua, Italy. (creator_code:org_t)
  • IMI DIRECT Consortium

Related titles

  • In:Diabetes: American Diabetes Association70:9, s. 2092-21061939-327X0012-1797

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