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Two-year MRI-define...
Two-year MRI-defined structural damage and patient-reported outcomes following surgery or exercise for meniscal tears in young adults
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- Clausen, Stine Haugaard (author)
- University of Southern Denmark
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- Skou, Søren T. (author)
- University of Southern Denmark
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- Boesen, Mikael Ploug (author)
- Copenhagen University Hospital
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- Radev, Dimitar Ivanon (author)
- Copenhagen University Hospital
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- Kurt, Engin Yeter (author)
- Copenhagen University Hospital
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- Damsted, Camma (author)
- University of Southern Denmark
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- Hölmich, Per (author)
- Hvidovre Hospital
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- Lind, Martin (author)
- Aarhus University Hospital
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- Tørring, Sofus (author)
- Aalborg University Hospital
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- Isaksen, Christin (author)
- Silkeborg Regional Hospital
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- Varnum, Claus (author)
- Lillebaelt Hospital
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- Englund, Martin (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Thorlund, Jonas Bloch (author)
- University of Southern Denmark
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: British journal of sports medicine. - 0306-3674. ; 57:24
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http://dx.doi.org/10...
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Abstract
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- Objective: To investigate potential differences in structural knee joint damage assessed by MRI and patient-reported outcomes (PROMs) at 2-year follow-up between young adults randomised to early surgery or exercise and education with optional delayed surgery for a meniscal tear. Methods: A secondary analysis of a multicentre randomised controlled trial including 121 patients (18-40 years) with an MRI-verified meniscal tear. For this study, only patients with 2-year follow-up were included. The main outcomes were the difference in worsening of structural knee damage, assessed by MRI using the Anterior Cruciate Ligament OsteoArthrits Score, and the difference in change in the mean score of four Knee Injury and Osteoarthritis Outcome Score (KOOS4) subscales covering pain, symptoms, function in sport and recreation, and quality of life, from baseline to 2 years. Results: In total, 82/121 (68%) patients completed the 2-year follow-up (39 from the surgical group and 43 from the exercise group). MRI-defined cartilage damage had developed or progressed in seven (9.1%) patients and osteophytes developed in two (2.6%) patients. The worsening of structural damage from baseline to 2-year follow-up was similar between groups. The mean (95% CI) adjusted differences in change in KOOS4 between intervention groups from baseline to 2 years was -1.4 (-9.1, 6.2) points. The mean improvement in KOOS4 was 16.4 (10.4, 22.4) in the surgical group and 21.5 (15.0, 28.0) in the exercise group. No between group differences in improvement were found in the KOOS subscales. Conclusions: The 2-year worsening of MRI-defined structural damage was limited and similar in young adult patients with a meniscal tear treated with surgery or exercise with optional delayed surgery. Both groups had similar clinically relevant improvements in KOOS4, suggesting the choice of treatment strategy does not impact 2-year structural knee damage or PROMs. Trial registration number: NCT02995551.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Arthroscopy
- Exercise Therapy
- Meniscus
- Osteoarthritis
Publication and Content Type
- art (subject category)
- ref (subject category)
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Clausen, Stine H ...
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Skou, Søren T.
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Boesen, Mikael P ...
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Radev, Dimitar I ...
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Kurt, Engin Yete ...
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Damsted, Camma
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Hölmich, Per
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Lind, Martin
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Tørring, Sofus
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Isaksen, Christi ...
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Varnum, Claus
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Englund, Martin
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Thorlund, Jonas ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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British journal ...
- By the university
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Lund University