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Two succeeding fibr...
Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring
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- Jiang, Dongsheng (author)
- Helmholtz Zentrum München
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- Correa-Gallegos, Donovan (author)
- Helmholtz Zentrum München
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- Christ, Simon (author)
- Helmholtz Zentrum München
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- Stefanska, Ania (author)
- Helmholtz Zentrum München
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- Liu, Juan (author)
- Helmholtz Zentrum München
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- Ramesh, Pushkar (author)
- Helmholtz Zentrum München
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- Rajendran, Vijayanand (author)
- Helmholtz Zentrum München
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- De Santis, Martina M. (author)
- Lund University,Lunds universitet,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,Lung Bioengineering and Regeneration,Lund University Research Groups,Helmholtz Zentrum München
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- Wagner, Darcy E. (author)
- Lund University,Lunds universitet,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,Lung Bioengineering and Regeneration,Lund University Research Groups,German Center for Lung Research (DZL),Helmholtz Zentrum München
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- Rinkevich, Yuval (author)
- German Center for Lung Research (DZL),Helmholtz Zentrum München
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(creator_code:org_t)
- 2018-03-28
- 2018
- English 10 s.
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In: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 20:4, s. 422-431
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Abstract
Subject headings
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- During fetal development, mammalian back-skin undergoes a natural transition in response to injury, from scarless regeneration to skin scarring. Here, we characterize dermal morphogenesis and follow two distinct embryonic fibroblast lineages, based on their history of expression of the engrailed 1 gene. We use single-cell fate-mapping, live three dimensional confocal imaging and in silico analysis coupled with immunolabelling to reveal unanticipated structural and regional complexity and dynamics within the dermis. We show that dermal development and regeneration are driven by engrailed 1-history-naive fibroblasts, whose numbers subsequently decline. Conversely, engrailed 1-history-positive fibroblasts possess scarring abilities at this early stage and their expansion later on drives scar emergence. The transition can be reversed, locally, by transplanting engrailed 1-naive cells. Thus, fibroblastic lineage replacement couples the decline of regeneration with the emergence of scarring and creates potential clinical avenues to reduce scarring.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jiang, Dongsheng
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Correa-Gallegos, ...
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Christ, Simon
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Stefanska, Ania
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Liu, Juan
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Ramesh, Pushkar
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show more...
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Rajendran, Vijay ...
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De Santis, Marti ...
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Wagner, Darcy E.
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Rinkevich, Yuval
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Cell Biol ...
- By the university
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Lund University