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  • Jakus, Nina (author)

Improved survival of left ventricular assist device carriers in Europe according to implantation eras : results from the PCHF-VAD registry

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-05-24
  • Wiley,2022
  • 11 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9fc7427f-8d31-4de7-a73f-e26871691ac3
  • https://lup.lub.lu.se/record/9fc7427f-8d31-4de7-a73f-e26871691ac3URI
  • https://doi.org/10.1002/ejhf.2526DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149672699URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims: Temporal changes in patient selection and major technological developments have occurred in the field of left ventricular assist devices (LVADs), yet analyses depicting this trend are lacking for Europe. We describe the advances of European LVAD programmes from the PCHF-VAD registry across device implantation eras. Methods and results: Of 583 patients from 13 European centres in the registry, 556 patients (mean age 53 ± 12 years, 82% male) were eligible for this analysis. Patients were divided into eras (E) by date of LVAD implantation: E1 from December 2006 to December 2012 (6 years), E2 from January 2013 to January 2020 (7 years). Patients implanted more recently were older with more comorbidities, but less acutely ill. Receiving an LVAD in E2 was associated with improved 1-year survival in adjusted analysis (hazard ratio [HR] 0.58, 95% confidence interval [CI] 0.35–0.98; p = 0.043). LVAD implantation in E2 was associated with a significantly lower chance of heart transplantation (adjusted HR 0.40, 95% CI 0.23–0.67; p = 0.001), and lower risk of LVAD-related infections (adjusted HR 0.64, 95% CI 0.43–0.95; p = 0.027), both in unadjusted and adjusted analyses. The adjusted risk of haemocompatibility-related events decreased (HR 0.60, 95% CI 0.39–0.91; p = 0.016), while heart failure-related events increased in E2 (HR 1.67, 95% CI 1.02–2.75; p = 0.043). Conclusion: In an analysis depicting the evolving landscape of continuous-flow LVAD carriers in Europe over 13 years, a trend towards better survival was seen in recent years, despite older recipients with more comorbidities, potentially attributable to increasing expertise of LVAD centres, improved patient selection and pump technology. However, a smaller chance of undergoing heart transplantation was noted in the second era, underscoring the relevance of improved outcomes on LVAD support.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Brugts, Jasper J.Erasmus University Medical Center (author)
  • Claggett, BrianBrigham and Women's Hospital / Harvard Medical School (author)
  • Timmermans, PhilippeUniversity Hospitals Leuven (author)
  • Pouleur, Anne CatherineSaint-Luc University Hospital,Catholic University of Louvain (author)
  • Rubiś, PawelJagiellonian University (author)
  • Van Craenenbroeck, Emeline M.Antwerp University Hospital (author)
  • Gaizauskas, EdvinasVilnius University (author)
  • Barge-Caballero, Eduardo (author)
  • Paolillo, StefaniaUniversity of Naples Federico II (author)
  • Grundmann, Sebastian (author)
  • D'Amario, DomenicoPoliclinico Universitario Agostino Gemelli (author)
  • Braun, OscarLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-oos (author)
  • Gkouziouta, AggelikiOnassis Cardiac Surgery Center, Athens (author)
  • Meyns, BartUniversity Hospitals Leuven (author)
  • Droogne, WalterUniversity Hospitals Leuven (author)
  • Wierzbicki, KarolJagiellonian University (author)
  • Holcman, KatarzynaJagiellonian University (author)
  • Planinc, Ivo (author)
  • Skoric, Bosko (author)
  • Flammer, Andreas J.University Hospital of Zurich (author)
  • Gasparovic, Hrvoje (author)
  • Biocina, Bojan (author)
  • Lund, Lars H.Karolinska Institutet,Karolinska Institute (author)
  • Milicic, Davor (author)
  • Ruschitzka, FrankUniversity Hospital of Zurich (author)
  • Cikes, Maja (author)
  • Erasmus University Medical CenterBrigham and Women's Hospital / Harvard Medical School (creator_code:org_t)
  • PCHF-VAD registry

Related titles

  • In:European Journal of Heart Failure: Wiley24:7, s. 1305-13151388-98421879-0844

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