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Granulocyte-stimula...
Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
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Socie, Gerard (author)
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Mary, Jean-Yves (author)
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Schrezenmeier, Hubert (author)
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Marsh, Judith (author)
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Bacigalupo, Andrea (author)
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Locasciulli, Anna (author)
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Fuehrer, Monica (author)
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- Békássy, Albert (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Tichelli, Andre (author)
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Passweg, Jakob (author)
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(creator_code:org_t)
- 2006-11-16
- 2007
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 109:7, s. 2794-2796
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http://dx.doi.org/10... (free)
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Abstract
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- Previous studies suggested a link between the use of G-CSF and increased incidence of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) after immunosuppressive therapy (IST) for severe aplastic anemia (SAA). This European survey included 840 patients who received a first-line IST with (43%) or without (57%) G-CSF. The incidences of MDS/AML in patients who did or did not receive G-CSF were 10.9% and 5.8%, respectively. A significantly higher hazard (1.9) of MDS/AML was associated with use of G-CSF. Relapse of aplastic anemia was not associated with a worse outcome in patients who did not receive G-CSIF as first therapy, whereas relapse was associated with a significantly worse outcome in those patients who received G-CSF. These results emphasize the necessity of the current European randomized trial comparing IST with or without G-CSF and to alert physicians that adding G-CSIF to IST is currently not standard treatment for SAA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- art (subject category)
- ref (subject category)
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Blood
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- By the author/editor
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Socie, Gerard
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Mary, Jean-Yves
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Schrezenmeier, H ...
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Marsh, Judith
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Bacigalupo, Andr ...
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Locasciulli, Ann ...
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show more...
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Fuehrer, Monica
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Békássy, Albert
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Tichelli, Andre
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Passweg, Jakob
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University