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Androgen receptor p...
Androgen receptor polymorphism dependent variation in prostate specific antigen concentrations of European men.
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- Bentmar Holgersson, Magdalena (author)
- Lund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Bjartell, Anders (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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Wu, Frederick C W (author)
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Huhtaniemi, Ilpo T (author)
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O'Neill, Terence W (author)
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Pendleton, Neil (author)
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Vanderschueren, Dirk (author)
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Lean, Michael E J (author)
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Han, Thang S (author)
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Finn, Joseph D (author)
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Kula, Krzysztof (author)
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Forti, Gianni (author)
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Casanueva, Felipe F (author)
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Bartfai, György (author)
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Punab, Margus (author)
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- Giwercman, Yvonne (author)
- Lund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755. ; 23:10, s. 2048-2056
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
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- Background Androgens acting via the androgen receptor (AR) stimulate production of prostate specific antigen (PSA), which is a clinical marker of prostate cancer (PCa). Since genetic variants in the AR may have a significant impact on the risk of being diagnosed with PCa, the aim was to investigate if AR-variants were associated with the risk of having PSA above clinically used cut-off thresholds of 3 or 4 ng/mL in men without PCa. Methods Men without PCa history (n=1744) were selected from the European Male Ageing Study (EMAS) cohort of 40-80 year old men from 8 different European centers. Using linear and logistic regression models, with age and center as covariates, we investigated whether AR-variants (CAG repeat-length and/or SNP genotype) were associated with having serum PSA concentrations above 3 or 4 ng/mL, which often are set as cut-off concentrations for further investigation of PCa. Results Carriers of the SNP rs1204038 A-allele (16% of the men) were more likely to have PSA>3 and 4 ng/mL (OR; 95%CI 1.65; 1.13-2.40 and 1.87; 1.18-2.96, respectively) than G-allele carriers. They also had shorter CAG-repeats (median 20 vs. 23, p<0.0005), but CAG repeat length per se did not affect the PSA concentrations. Conclusion The A-allele of the SNP rs1204038 gives a 65% higher risk of having PSA above 3 ng/mL than the G-allele in men without PCa, and thereby an increased risk of being referred for further examination on suspicion of PCa. Impact Serum PSA as a clinical marker could be improved by adjustment for AR-genotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Bentmar Holgerss ...
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Giwercman, Aleks ...
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Bjartell, Anders
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Wu, Frederick C ...
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Huhtaniemi, Ilpo ...
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O'Neill, Terence ...
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show more...
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Pendleton, Neil
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Vanderschueren, ...
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Lean, Michael E ...
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Han, Thang S
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Finn, Joseph D
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Kula, Krzysztof
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Forti, Gianni
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Casanueva, Felip ...
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Bartfai, György
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Punab, Margus
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Giwercman, Yvonn ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Cancer Epidemiol ...
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Lund University