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  • Khayyeri, HanifehLund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Sweden (author)

Diminishing effects of mechanical loading over time during rat Achilles tendon healing

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-12-14
  • Public Library of Science (PLoS),2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:a34abbb7-507e-4c82-ab82-73cb5466a8ab
  • https://lup.lub.lu.se/record/a34abbb7-507e-4c82-ab82-73cb5466a8abURI
  • https://doi.org/10.1371/journal.pone.0236681DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-172610URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Funding Agencies|European Communitys Seventh Framework Program (FP7/2007-2013) [262348]; Marie Curie Intra-European Fellowship for Career DevelopmentEuropean Union (EU) [PIEF-GA-2012-626941]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation [2017.0221]
  • Mechanical loading affects tendon healing and recovery. However, our understanding about how physical loading affects recovery of viscoelastic functions, collagen production and tissue organisation is limited. The objective of this study was to investigate how different magnitudes of loading affects biomechanical and collagen properties of healing Achilles tendons over time. Achilles tendon from female Sprague Dawley rats were cut transversely and divided into two groups; normal loading (control) and reduced loading by Botox (unloading). The rats were sacrificed at 1, 2- and 4-weeks post-injury and mechanical testing (creep test and load to failure), small angle x-ray scattering (SAXS) and histological analysis were performed. The effect of unloading was primarily seen at the early time points, with inferior mechanical and collagen properties (SAXS), and reduced histological maturation of the tissue in unloaded compared to loaded tendons. However, by 4 weeks no differences remained. SAXS and histology revealed heterogeneous tissue maturation with more mature tissue at the peripheral region compared to the center of the callus. Thus, mechanical loading advances Achilles tendon biomechanical and collagen properties earlier compared to unloaded tendons, and the spatial variation in tissue maturation and collagen organization across the callus suggests important regional (mechano-) biological activities that require more investigation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hammerman, MalinLinköpings universitet,Linköping University,Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Lund Univ, Sweden(Swepub:liu)malha77 (author)
  • Turunen, Mikael J.University of Eastern Finland,Univ Eastern Finland, Finland(Swepub:lu)bme-mkt (author)
  • Blomgran, ParmisLinköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten(Swepub:liu)parse45 (author)
  • Notermans, ThomasLund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Sweden(Swepub:lu)th7608no (author)
  • Guizar-Sicairos, ManuelPaul Scherrer Institute,Paul Scherrer Inst, Switzerland (author)
  • Eliasson, Pernilla T.Linköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten(Swepub:liu)perel67 (author)
  • Aspenberg, PerLinköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Ortopedkliniken i Linköping(Swepub:liu)peras36 (author)
  • Isaksson, HannaLund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)soli-hai (author)
  • Institutionen för biomedicinsk teknikInstitutioner vid LTH (creator_code:org_t)

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  • In:PLoS ONE: Public Library of Science (PLoS)15:12 December1932-6203

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