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Genome-wide associa...
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Barrett, Jennifer H.Karolinska Institutet
(author)
Genome-wide association study identifies three new melanoma susceptibility loci
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-10-09
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Springer Science and Business Media LLC,2011
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:a377bfc7-3220-4e86-aa3b-acc8b4b00ab7
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https://lup.lub.lu.se/record/2254203URI
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https://doi.org/10.1038/ng.959DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123530969URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10(-5) and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10(-3): an SNP in ATM (rs1801516, overall P = 3.4 x 10(-9)), an SNP in MX2 (rs45430, P = 2.9 x 10-9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 x 10(-10)). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 x 10(-7) under a fixed-effects model and P = 1.2 x 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
Subject headings and genre
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Iles, Mark M.
(author)
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Harland, Mark
(author)
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Taylor, John C.
(author)
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Aitken, Joanne F.
(author)
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Andresen, Per Arne
(author)
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Akslen, Lars A.
(author)
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Armstrong, Bruce K.
(author)
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Avril, Marie-Francoise
(author)
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Azizi, Esther
(author)
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Bakker, Bert
(author)
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Bergman, Wilma
(author)
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Bianchi-Scarra, Giovanna
(author)
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Bressac-de Paillerets, Brigitte
(author)
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Calista, Donato
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Cannon-Albright, Lisa A.
(author)
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Corda, Eve
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Cust, Anne E.
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Debniak, Tadeusz
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Duffy, David
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Dunning, Alison M.
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Easton, Douglas F.
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Friedman, Eitan
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Galan, Pilar
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Ghiorzo, Paola
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Giles, Graham G.
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Hansson, Johan
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Hocevar, Marko
(author)
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Hoeiom, VeronicaKarolinska Institutet
(author)
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Hopper, John L.
(author)
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Ingvar, ChristianLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-cin
(author)
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Janssen, Bart
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Jenkins, Mark A.
(author)
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Jönsson, Göran BLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-gjo
(author)
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Kefford, Richard F.
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Landi, Giorgio
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Landi, Maria Teresa
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Lang, Julie
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Lubinski, Jan
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Mackie, Rona
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Malvehy, Josep
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Martin, Nicholas G.
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Molven, Anders
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Montgomery, Grant W.
(author)
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van Nieuwpoort, Frans A.
(author)
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Novakovic, Srdjan
(author)
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Olsson, HåkanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol
(author)
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Pastorino, Lorenza
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Puig, Susana
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Puig-Butille, Joan Anton
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Randerson-Moor, Juliette
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Snowden, Helen
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Tuominen, RainerKarolinska Institutet
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VanBelle, Patricia
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van der Stoep, Nienke
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Whiteman, David C.
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Zelenika, Diana
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Han, Jiali
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Fang, Shenying
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Lee, Jeffrey E.
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Wei, Qingyi
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Lathrop, G. Mark
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Gillanders, Elizabeth M.
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Brown, Kevin M.
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Goldstein, Alisa M.
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Kanetsky, Peter A.
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Mann, Graham J.
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MacGregor, Stuart
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Elder, David E.
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Amos, Christopher I.
(author)
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Hayward, Nicholas K.
(author)
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Gruis, Nelleke A.
(author)
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Demenais, Florence
(author)
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Bishop, Julia A. Newton
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Bishop, D. Timothy
(author)
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Karolinska InstitutetKirurgi, Lund
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC43:11, s. 1108-11131546-17181061-4036
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Barrett, Jennife ...
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Iles, Mark M.
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Harland, Mark
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Taylor, John C.
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Aitken, Joanne F ...
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Andresen, Per Ar ...
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Akslen, Lars A.
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Armstrong, Bruce ...
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Avril, Marie-Fra ...
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Azizi, Esther
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Bakker, Bert
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Bergman, Wilma
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Bianchi-Scarra, ...
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Bressac-de Paill ...
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Calista, Donato
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Cannon-Albright, ...
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Corda, Eve
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Cust, Anne E.
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Debniak, Tadeusz
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Duffy, David
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Dunning, Alison ...
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Easton, Douglas ...
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Friedman, Eitan
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Galan, Pilar
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Ghiorzo, Paola
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Giles, Graham G.
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Hansson, Johan
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Hocevar, Marko
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Hoeiom, Veronica
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Hopper, John L.
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Ingvar, Christia ...
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Janssen, Bart
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Jenkins, Mark A.
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Jönsson, Göran B
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Kefford, Richard ...
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Landi, Giorgio
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Landi, Maria Ter ...
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Lang, Julie
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Lubinski, Jan
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Mackie, Rona
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Malvehy, Josep
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Martin, Nicholas ...
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Molven, Anders
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Montgomery, Gran ...
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van Nieuwpoort, ...
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Novakovic, Srdja ...
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Olsson, Håkan
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Pastorino, Loren ...
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Puig, Susana
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Puig-Butille, Jo ...
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Randerson-Moor, ...
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Snowden, Helen
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Tuominen, Rainer
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VanBelle, Patric ...
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van der Stoep, N ...
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Whiteman, David ...
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Zelenika, Diana
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Han, Jiali
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Fang, Shenying
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Lee, Jeffrey E.
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Wei, Qingyi
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Lathrop, G. Mark
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Gillanders, Eliz ...
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Brown, Kevin M.
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Goldstein, Alisa ...
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Kanetsky, Peter ...
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Mann, Graham J.
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MacGregor, Stuar ...
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Elder, David E.
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Amos, Christophe ...
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Hayward, Nichola ...
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Gruis, Nelleke A ...
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- MEDICAL AND HEALTH SCIENCES
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Nature Genetics
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Lund University
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Karolinska Institutet