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Differential Glucos...
Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.
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- Esguerra, Jonathan (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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- Bolmeson, Caroline (author)
- Lund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Evolutionär ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Other operations, LTH,Faculty of Engineering, LTH,Evolutionary ecology,Department of Biology,Faculty of Science
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- Cilio, Corrado (author)
- Lund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups
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- Eliasson, Lena (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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(creator_code:org_t)
- 2011-04-07
- 2011
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:4
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Abstract
Subject headings
Close
- The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Islets of Langerhans/*drug effects/*metabolism
- MicroRNAs/*genetics
- Glucose/*pharmacology
- Gene Expression Profiling
- Animals
- Type 2/*metabolism
- Diabetes Mellitus
- Polymerase Chain Reaction
- Rats
- Wistar
Publication and Content Type
- art (subject category)
- ref (subject category)
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