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Life is pain : Fibr...
Life is pain : Fibromyalgia as a nexus of multiple liability distributions
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- Moscati, Arden (author)
- Icahn School of Medicine at Mount Sinai
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- Faucon, Annika B. (author)
- Vanderbilt University Medical Center
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- Arnaiz-Yépez, Cayetana (author)
- Vanderbilt University Medical Center
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- Lönn, Sara Larsson (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Sundquist, Jan (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University
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- Sundquist, Kristina (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University
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- Belbin, Gillian M. (author)
- Icahn School of Medicine at Mount Sinai
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- Nadkarni, Girish (author)
- Icahn School of Medicine at Mount Sinai
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- Cho, Judy H. (author)
- Icahn School of Medicine at Mount Sinai
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- Loos, Ruth J.F. (author)
- Icahn School of Medicine at Mount Sinai
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- Davis, Lea K. (author)
- Vanderbilt University Medical Center
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- Kendler, Kenneth S. (author)
- Virginia Commonwealth University
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(creator_code:org_t)
- 2023
- 2023
- English 12 s.
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In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. - 1552-4841. ; 192:7-8, s. 171-182
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Abstract
Subject headings
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- Fibromyalgia is a complex disease of unclear etiology that is complicated by difficulties in diagnosis, treatment, and clinical heterogeneity. To clarify this etiology, healthcare-based data are leveraged to assess the influences on fibromyalgia in several domains. Prevalence is less than 1% of females in our population register data, and about 1/10th that in males. Fibromyalgia often presents with co-occurring conditions including back pain, rheumatoid arthritis, and anxiety. More comorbidities are identified with hospital-associated biobank data, falling into three broad categories of pain-related, autoimmune, and psychiatric disorders. Selecting representative phenotypes with published genome-wide association results for polygenic scoring, we confirm genetic predispositions to psychiatric, pain sensitivity, and autoimmune conditions show associations with fibromyalgia, although these may differ by ancestry group. We conduct a genome-wide association analysis of fibromyalgia in biobank samples, which did not result in any genome-wide significant loci; further studies with increased sample size are necessary to identify specific genetic effects on fibromyalgia. Overall, fibromyalgia appears to have strong clinical and likely genetic links to several disease categories, and could usefully be understood as a composite manifestation of these etiological sources.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- epidemiology
- etiology
- fibromyalgia
- genetics
- phenome
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Moscati, Arden
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Faucon, Annika B ...
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Arnaiz-Yépez, Ca ...
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Lönn, Sara Larss ...
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Sundquist, Jan
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Sundquist, Krist ...
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show more...
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Belbin, Gillian ...
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Nadkarni, Girish
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Cho, Judy H.
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Loos, Ruth J.F.
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Davis, Lea K.
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Kendler, Kenneth ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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American Journal ...
- By the university
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Lund University