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EAU-EANM Consensus ...
EAU-EANM Consensus Statements on the Role of Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Patients with Prostate Cancer and with Respect to [177Lu]Lu-PSMA Radioligand Therapy
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- Fanti, Stefano (author)
- University of Bologna
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Briganti, Alberto (author)
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- Emmett, Louise (author)
- St Vincent's Hospital, Sydney
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Fizazi, Karim (author)
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- Gillessen, Silke (author)
- Oncology Institute of Southern Switzerland
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- Goffin, Karolien (author)
- University Hospitals Leuven
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- Hadaschik, Boris A. (author)
- University of Duisburg-Essen
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- Herrmann, Ken (author)
- University of Duisburg-Essen
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- Kunikowska, Jolanta (author)
- Medical University of Warsaw
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- Maurer, Tobias (author)
- University Medical Center Hamburg-Eppendorf
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- MacLennan, Steven (author)
- University of Aberdeen
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Mottet, Nicolas (author)
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- Murphy, Declan G. (author)
- University of Melbourne
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- Oprea-Lager, Daniela E. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- O'Sullivan, Joe M. (author)
- Queen's University Belfast
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- Oyen, Wim J.G. (author)
- Humanitas University
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- Rouvière, Olivier (author)
- Hôpital Edouard Herriot
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- Sartor, Oliver (author)
- Tulane University School of Medicine
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- Stenzl, Arnulf (author)
- University of Tübingen
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- Van Poppel, Hendrik (author)
- Catholic University of Leuven
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- Walz, Jochen (author)
- Institut Paoli-Calmettes
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Witjes, Wim (author)
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- Bjartell, Anders (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English 7 s.
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In: European Urology Oncology. - : Elsevier BV. - 2588-9311. ; 5:5, s. 530-536
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- BACKGROUND: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is useful for selected clinical indications in patients with prostate cancer (PCa) but it may have broader clinical utility owing to the emergence of lutetium-177-PSMA-617 ([177Lu]Lu-PSMA) therapy. However, robust data regarding the impact of PSMA PET/CT on patient management and treatment are lacking, and in many areas, the role of next-generation imaging has not been defined. OBJECTIVE: To assess expert opinion on the use of PSMA-based imaging and therapy to develop interim guidance. DESIGN, SETTING, AND PARTICIPANTS: A panel of 21 PCa experts from various disciplines received thematic topics and relevant literature. A questionnaire to assess proposed guidance statements regarding PSMA PET/CT and [177Lu]Lu-PSMA therapy was developed for completion remotely in a first e-Delphi round. A subsequent panel discussion was conducted during a 1-d meeting, which included a second Delphi round. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Panellists voted anonymously on statements using a nine-point Likert scale from 1 = strongly disagree to 9 = strongly agree. Median scores were calculated and consensus was assessed using methods proposed by the Research and Development (RAND) corporation. RESULTS AND LIMITATIONS: Statements were developed to cover the following topics: PSMA PET/CT utility, clinical use, and choice of tracer; patient selection; and management of patients receiving [177Lu]Lu-PSMA for metastatic PCa. Consensus was reached for 33/36 statements. In-group bias is a potential limitation, as some statements were rephrased during discussions at the 1-d meeting. CONCLUSIONS: Adoption of PSMA PET/CT as an imaging tool to guide [177Lu]Lu-PSMA therapy should be supported by indications for appropriate use. PATIENT SUMMARY: A panel of experts in prostate cancer reached a consensus for the majority of statements proposed regarding the role of prostate-specific membrane antigen (PSMA)-based imaging and therapy, particularly the use of PSMA-based imaging in patients suitable for [177Lu]Lu-PSMA therapy and the need to perform PSMA-based imaging before considering patients as candidates for this therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Computed tomography
- Consensus
- Diagnosis
- Lutetium
- Patient selection
- Positron emission tomography
- Prostate cancer
- Prostate-specific membrane antigen
- Radioactive tracer
- Therapy
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Fanti, Stefano
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Briganti, Albert ...
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Emmett, Louise
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Fizazi, Karim
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Gillessen, Silke
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Goffin, Karolien
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show more...
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Hadaschik, Boris ...
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Herrmann, Ken
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Kunikowska, Jola ...
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Maurer, Tobias
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MacLennan, Steve ...
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Mottet, Nicolas
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Murphy, Declan G ...
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Oprea-Lager, Dan ...
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O'Sullivan, Joe ...
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Oyen, Wim J.G.
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Rouvière, Olivie ...
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Sartor, Oliver
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Stenzl, Arnulf
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Van Poppel, Hend ...
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Walz, Jochen
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Witjes, Wim
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Bjartell, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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European Urology ...
- By the university
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Lund University