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IL-16/miR-125a axis...
IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation
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- Smith, Siobhan (author)
- Royal College of Surgeons in Ireland
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- Wu, Pei Wen (author)
- Cedars-Sinai Medical Center
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- Seo, Jane J. (author)
- Cedars-Sinai Medical Center
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- Fernando, Thilini (author)
- Cedars-Sinai Medical Center
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- Jin, Mengyao (author)
- Cedars-Sinai Medical Center
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- Contreras, Jorge (author)
- Cedars-Sinai Medical Center
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- Montano, Erica N. (author)
- Cedars-Sinai Medical Center
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- Gabhann, Joan Ní (author)
- Royal College of Surgeons in Ireland
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- Cunningham, Kyle (author)
- Cedars-Sinai Medical Center
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- Widaa, Amro (author)
- Royal College of Surgeons in Ireland
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- McCarthy, Eoghan M. (author)
- Beaumont Hospital, Dublin
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- Molloy, Eamonn S. (author)
- St Vincent's University Hospital
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- Kearns, Grainne (author)
- Beaumont Hospital, Dublin
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- Murphy, Conor C. (author)
- Royal College of Surgeons in Ireland
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- Kong, Weiping (author)
- China-Japan Friendship Hospital
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- Björkbacka, Harry (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Kornfeld, Hardy (author)
- University of Massachusetts
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- Forbess, Lindsy (author)
- Cedars-Sinai Medical Center
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- Venuturupalli, Swamy (author)
- Cedars-Sinai Medical Center
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- Ishimori, Mariko (author)
- Cedars-Sinai Medical Center
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- Wallace, Daniel (author)
- Cedars-Sinai Medical Center
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- Weisman, Michael H. (author)
- Cedars-Sinai Medical Center
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- Jefferies, Caroline A. (author)
- Cedars-Sinai Medical Center
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(creator_code:org_t)
- 2018-08-09
- 2018
- English.
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In: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 3:15
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http://dx.doi.org/10... (free)
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http://insight.jci.o...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Severe lung inflammation and alveolar hemorrhage can be life-threatening in systemic lupus erythematosus (SLE) patients if not treated early and aggressively. Neutrophil influx is the driver key of this pathology, but little is known regarding the molecular events regulating this recruitment. Here, we uncover a role for IL-16/mir-125a in this pathology and show not only that IL-16 is a target for miR-125a but that reduced miR-125a expression in SLE patients associates with lung involvement. Furthermore, in the pristane model of acute "SLE-like" lung inflammation and alveolar hemorrhage, we observed reduced pulmonary miR-125a and enhanced IL-16 expression. Neutrophil infiltration was markedly reduced in the peritoneal lavage of pristane-treated IL-16-deficient mice and elevated following i.n. delivery of IL-16. Moreover, a miR-125a mimic reduced pristane-induced IL-16 expression and neutrophil recruitment and rescued lung pathology. Mechanistically, IL-16 acts directly on the pulmonary epithelium and markedly enhances neutrophil chemoattractant expression both in vitro and in vivo, while the miR-125a mimic can prevent this. Our results reveal a role for miR-125a/IL-16 in regulating lung inflammation and suggest this axis may be a therapeutic target for management of acute lung injury in SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Autoimmunity
- Chemokines
- Immunology
- Lupus
- Neutrophils
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Smith, Siobhan
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Wu, Pei Wen
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Seo, Jane J.
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Fernando, Thilin ...
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Jin, Mengyao
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Contreras, Jorge
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show more...
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Montano, Erica N ...
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Gabhann, Joan Ní
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Cunningham, Kyle
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Widaa, Amro
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McCarthy, Eoghan ...
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Molloy, Eamonn S ...
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Kearns, Grainne
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Murphy, Conor C.
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Kong, Weiping
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Björkbacka, Harr ...
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Kornfeld, Hardy
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Forbess, Lindsy
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Venuturupalli, S ...
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Ishimori, Mariko
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Wallace, Daniel
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Weisman, Michael ...
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Jefferies, Carol ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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JCI Insight
- By the university
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Lund University